Beyond the diffraction limit: sub-diffraction T-ray biochip sensing using planar metamaterials

超越衍射极限：使用平面超材料的亚衍射 T 射线生物芯片传感

• 批准号: DP140104651
• 负责人: Prof Derek Abbott
• 金额: $ 28.31万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140104651
• 关键词: Beyond; diffraction; limit; sub; ray

T-rays are able to detect small changes in molecular structure and different isomeric and intermolecular configurations. With a comparatively long wavelength (0.3 mm at 1 THz), diffraction limits its use for imaging small biosamples. A method for achieving sub-diffraction sensing, required for biochips, is to adopt near-field techniques. However, due to the small biosample masses, there is a critical need to enhance the response. This project will investigate a planar metamaterial thin-film T-ray sensor, for a new leap in non-invasive biochip sensing. This outcome will build downstream IP for rapid screening of DNA and proteins for healthcare. The project will also elucidate the science of T-ray interaction with biomaterials at small scales.

T射线能够探测分子结构的微小变化以及不同的同分异构体和分子间构型。由于波长相对较长（1 THz时为0.3 mm），衍射限制了其用于成像小生物样品的用途。实现生物芯片所需的亚衍射传感的方法是采用近场技术。然而，由于生物样品量小，迫切需要增强响应。本计画将研究一种平面超材料薄膜T射线感测器，为非侵入式生物晶片感测的新飞跃。这一成果将建立下游IP，用于快速筛选用于医疗保健的DNA和蛋白质。该项目还将阐明T射线与生物材料在小尺度上相互作用的科学。