SCCOR in Translational Research in Acute Lung Injury

SCCOR 在急性肺损伤转化研究中的应用

• 批准号: 6673301
• 负责人: Thomas R Martin
• 金额: $ 291.59万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6673301
• 关键词: adult respiratory distress syndrome; clinical research; lung injury

DESCRIPTION (provided by applicant): The overall objective of this application for a Specialized Center of Clinical Research is to investigate novel aspects of the pathogenesis and treatment of acute lung injury in humans. Acute lung injury is an important clinical problem in critically ill patients that affects more than 100,000 patients annually in the United States. Our major hypothesis is that new advances in understanding pathogenesis and treatment will come from research approaches that take into account the complexity of biological responses in humans. Past approaches to this disease have emphasized single pathways in pathogenesis and treatment, but recent developments in biotechnology have made it possible to approach lung injury from a systems point of view that recognizes the importance of multiple pathways in the injury and repair process. Our application brings together a cohesive group of six projects (three clinical and three basic) and three cores, Administrative, Biotechnology, and Educational. Project 1 will investigate the complexity of host determinants of inflammatory responses in normal and critically ill patients; Project 2 will perform a randomized trial of a new treatment program in survivors of acute lung injury, recognizing the complex clinical needs of these patients; Project 3 will perform pilot projects of new treatments with the aim of taking forward positive results to larger clinical trials; Project 4 investigates the complex early interactions between bacteria and the alveolar environment that influence bacterial pathogenesis; Project 5 investigates a novel new pathway that protects mice from systemic sepsis; and Project 6 investigates the complex mechanisms that control alveolar epithelial injury. The proposed studies evolve logically from ongoing studies in the current Seattle ARDS Research Program. The proposed SCCOR Program will enhance understanding of the pathogenesis of lung injury and could lead to new treatments and improved long-term outcome for patients with acute lung injury.

描述（由申请人提供）：本次申请的临床研究专业中心的总体目标是研究人类急性肺损伤的发病机制和治疗的新方面。急性肺损伤是危重患者的重要临床问题，在美国每年有超过10万例患者受到急性肺损伤的影响。我们的主要假设是，在理解发病机制和治疗方面的新进展将来自考虑到人类生物反应复杂性的研究方法。过去对这种疾病的研究强调了发病机制和治疗的单一途径，但最近生物技术的发展使得从系统的角度来研究肺损伤成为可能，这种观点认识到损伤和修复过程中多种途径的重要性。我们的申请汇集了六个项目（三个临床和三个基础）和三个核心，行政，生物技术和教育。