Center for Interdisciplinary Health Disparities Research

跨学科健康差异研究中心

• 批准号: 6657171
• 负责人: SARAH Jane GEHLERT
• 金额: $ 153.22万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-18 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6657171
• 关键词: behavioral /social science research tag; breast neoplasms; clinical research; health disparity; health services research tag

The specific aims of the Center for Interdisciplinary Health Disparities Research are to: Aim #1: bring together scientists from inside and outside the University and members of the community who are especially vulnerable to adverse health conditions to inform the Center's scientific agenda; Aim #2: foster investigations that consider health disparities from multiple levels of analysis via shared conceptual frameworks that integrate discipline-specific theories and methods; Aim #3: increase interest in health disparities among scientist and students from various disciplines and from community members; Aim #4: develop measures and methods that are appropriate for use with vulnerable populations and that allow factors at various levels (social/environmental, behavioral/psychological, and biological/genetic) to be analyzed together; Aim #5: increase existing knowledge on the social, behavioral, and biological factors that influence health disparities and the nature of their interactions; and, Aim #6: disseminate findings through channels established through the Center to as wide an audience as possible, including members of vulnerable populations, community-based organizations and agencies, and scientific investigators inside and outside the University. In its first five years, the Center will focus on group differences in breast cancer, notably why Black women in the US and West Africa experience breast cancers that occur at a younger age and are more aggressive and lethal than those of White women. McClintock (R01 # 1), based on an animal model of social regulation of mammary tumor biology developed in her laboratory, will compare the gene regulation in mammary tumors and the ovarian function of socially isolated and group-living rats. OIopade (R01# 2) will (a) look at the molecular characterization of primary patient samples in Nigeria and Chicago's South Side to see if alterations in BRCA1 contribute to breast cancer in younger Black women and (b) explore the McClintock model in primary patient samples. Gehlert and Masi (R01# 3; CBPR) will explore emic views of breast cancer and its treatment and test the McClintock model with community volunteers. In the lalffer, they will examine neighborhood and community factors (such as collective efficacy and crime), living situations and social connectedness, behavioral responses (such as vigilance and perceived stress), and biological (e.g., cortisol levels) and health outcomes (most notably breast cancer). Conzen (R01# 4) will study rate of mammary tumor growth, response to chemotherapy, and chemoprevention in two animal models. The Tissue Core will provide analysis of mammary tissue. Coordination and dissemination will occur through the Administrative Core, by means of Faculty Colloquium and Monthly Speaker Series, In-Service and Summer Apprenticeship programs, a Center Web site and Web page for communication with other CPHHDs, etc.

跨学科健康差异研究中心的具体目标是：目标1：将来自大学内外的科学家和特别容易受到不利健康状况影响的社区成员聚集在一起，为中心的科学议程提供信息；目标2：通过整合特定学科的理论和方法的共享概念框架，促进从多个层面的分析考虑健康差异的调查；目标3：提高科学家和来自不同学科的学生和社区成员对健康差异的兴趣；目标4：制定适用于弱势群体的措施和方法，并允许不同层面的因素(社会/环境、行为/心理和生物/遗传) 目标5：增加关于影响健康差距的社会、行为和生物因素及其相互作用性质的现有知识；目标6：通过中心建立的渠道向尽可能广泛的受众传播研究结果，包括弱势群体成员、基于社区的组织和机构以及大学内外的科学研究人员。 在最初的五年里，该中心将专注于乳腺癌的群体差异，特别是为什么美国和西非的黑人女性患乳腺癌的年龄更小，而且比白人女性更具侵袭性和致命性。McClintock(R01#1)基于她的实验室开发的乳腺肿瘤生物学社会调节的动物模型，将比较乳腺肿瘤的基因调节和社会隔离和群居大鼠的卵巢功能。OIopade(R01#2)将(A)研究尼日利亚和芝加哥南区的初级患者样本的分子特征，以确定BRCA1的变化是否会导致年轻黑人女性患乳腺癌，以及(B)在初级患者样本中探索McClintock模型。Gehlert和Masi(R01#3；CBPR)将探索对乳腺癌及其治疗的主要观点，并与社区志愿者一起测试McClintock模型。在Lalffer中，他们将检查邻居和社区因素(如集体效能和犯罪)、生活状况和社会联系、行为反应(如警觉和感知到的压力)、生物学因素(如皮质醇水平)和健康结果(最明显的是乳腺癌)。康森(R01#4)将在两个动物模型中研究乳腺肿瘤的生长速度、对化疗的反应和化学预防。组织核心将提供对乳腺组织的分析。协调和传播将通过行政核心、教师座谈会和每月演讲人系列、在职和暑期学徒等方式进行 程序、中心网站和用于与其他CPHHD进行交流的网页等。