Center for Interdisciplinary Health Disparities Research

跨学科健康差异研究中心

• 批准号: 7692457
• 负责人: SARAH Jane GEHLERT
• 金额: $ 10万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-18 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7692457
• 关键词: Africa; Age; Animal Model; BRCA1 gene; Behavioral; Biological; Biological Factors; Chemoprevention; Chicago; Communication; Communities; Condition; Crime; Discipline; Faculty; Fostering; Gene Expression Regulation; Genetic; Health; Health Status; Hydrocortisone; Internet; Investigation; Knowledge; Laboratories; Life; Mammary Neoplasms; Mammary gland; Measures; Methods; Modeling; Molecular; Nature; Neighborhoods; Nigeria; Outcome; Ovarian; Patients; Rate; Rattus; Regulation; Research; Research Personnel; Sampling; Scientist; Series; Services; Side; Site; Stress; Students; Testing; Tissues; Tumor Biology; Universities; Vulnerable Populations; Woman; base; chemotherapy; experience; health disparity; interest; malignant breast neoplasm; member; programs; psychologic; response; social; theories; tumor growth; vigilance; volunteer

The specific aims of the Center for Interdisciplinary Health Disparities Research are to: Aim #1: bring together scientists from inside and outside the University and members of the community who are especially vulnerable to adverse health conditions to inform the Center's scientific agenda; Aim #2: foster investigations that consider health disparities from multiple levels of analysis via shared conceptual frameworks that integrate discipline-specific theories and methods; Aim #3: increase interest in health disparities among scientist and students from various disciplines and from community members; Aim #4: develop measures and methods that are appropriate for use with vulnerable populations and that allow factors at various levels (social/environmental, behavioral/psychological, and biological/genetic) to be analyzed together; Aim #5: increase existing knowledge on the social, behavioral, and biological factors that influence health disparities and the nature of their interactions; and, Aim #6: disseminate findings through channels established through the Center to as wide an audience as possible, including members of vulnerable populations, community-based organizations and agencies, and scientific investigators inside and outside the University. In its first five years, the Center will focus on group differences in breast cancer, notably why Black women in the US and West Africa experience breast cancers that occur at a younger age and are more aggressive and lethal than those of White women. McClintock (R01 # 1), based on an animal model of social regulation of mammary tumor biology developed in her laboratory, will compare the gene regulation in mammary tumors and the ovarian function of socially isolated and group-living rats. OIopade (R01# 2) will (a) look at the molecular characterization of primary patient samples in Nigeria and Chicago's South Side to see if alterations in BRCA1 contribute to breast cancer in younger Black women and (b) explore the McClintock model in primary patient samples. Gehlert and Masi (R01# 3; CBPR) will explore emic views of breast cancer and its treatment and test the McClintock model with community volunteers. In the lalffer, they will examine neighborhood and community factors (such as collective efficacy and crime), living situations and social connectedness, behavioral responses (such as vigilance and perceived stress), and biological (e.g., cortisol levels) and health outcomes (most notably breast cancer). Conzen (R01# 4) will study rate of mammary tumor growth, response to chemotherapy, and chemoprevention in two animal models. The Tissue Core will provide analysis of mammary tissue. Coordination and dissemination will occur through the Administrative Core, by means of Faculty Colloquium and Monthly Speaker Series, In-Service and Summer Apprenticeship programs, a Center Web site and Web page for communication with other CPHHDs, etc.

跨学科健康差异研究中心的具体目标是：目标#1：汇集来自大学内外的科学家和特别容易受到不良健康状况影响的社区成员，以告知中心的科学议程;目标#2：通过整合学科的共享概念框架，促进从多个层面分析考虑健康差异的调查，具体理论和方法;目标3：提高各学科科学家和学生以及社区成员对健康差距的兴趣;目标4：制定适合弱势群体使用的措施和方法， 一起分析;目标5：增加对影响健康差异及其相互作用性质的社会，行为和生物因素的现有知识;以及，目标#6：通过中心建立的渠道向尽可能广泛的受众传播研究结果，包括弱势群体，社区组织和机构的成员，以及大学内外的科学调查人员。 在最初的五年里，该中心将专注于乳腺癌的群体差异，特别是为什么美国和西非的黑人妇女在更年轻的时候患上乳腺癌，并且比白色妇女更具侵略性和致命性。McClintock（R 01 # 1）基于其实验室开发的乳腺肿瘤生物学社会调节的动物模型，将比较乳腺肿瘤中的基因调节和社会隔离和群体生活大鼠的卵巢功能。OIopade（R01#2）将（a）研究尼日利亚和芝加哥南区主要患者样本的分子特征，以了解BRCA 1的改变是否有助于年轻黑人女性的乳腺癌，（B）探索主要患者样本的McClintock模型。Gehlert和马西（R01#3; CBPR）将探讨乳腺癌及其治疗的主位观点，并与社区志愿者一起测试McClintock模型。在拉弗，他们将检查邻里和社区因素（如集体效能和犯罪），生活情况和社会联系，行为反应（如警惕和感知压力），和生物（例如，皮质醇水平）和健康结果（最明显的是乳腺癌）。Conzen（R01#4）将在两种动物模型中研究乳腺肿瘤生长率、对化疗的反应和化学预防。组织芯将提供乳腺组织分析。协调和传播将通过行政核心，通过教师座谈会和每月演讲系列，在职和暑期学徒进行 程序、用于与其他CPHHD通信的中心网站和网页等。