Cognitive and Spatial Systems in Action

描述（由申请人提供）：致力于处理对象身份的腹侧视觉处理流与编码对象位置和身体运动的背侧流之间的区别指导了感知和动作的二十年研究。包括我们实验室的工作在内的许多证据表明，该模型需要改进。本建议中所述的这项工作有两个总的目标。第一个是在计算框架内建立一个行动系统模型。该模型包括两个解剖学和功能上不同的组件：动作表征系统，介导的下顶叶，和动作执行系统，介导的背流结构在额顶叶皮层。第二个总的目标是调和一个主要的临床综合征，identificamapraxia（IM），与最近的进展，在认知神经科学研究的行动。有四个具体目标。首先，我们将通过评估IM的两个亚型模型，将IM的多样呈现与动作系统的两个组成部分联系起来。其次，通过对IM患者的研究，我们将评估身体位置和身体运动信息的两种空间编码之间的区别。第三，我们将评估物体在完成熟练动作中的作用，以及在不同背景下使用的物体表征之间的区别。最后，我们将阐明用于编程动作的内部运动模型。拟议的研究计划预计将继续有助于我们理解的关系，不同的代表性和动态处理模块在正常和无序的行动，以及这些过程的神经解剖学基板。此外，它预计将显着推进我们对IM的理解，IM是一种常见的临床疾病，其表现、亚型和神经解剖学基础仍然知之甚少。

DESCRIPTION (provided by applicant): The distinction between a ventral visual processing stream devoted to processing object identity and a dorsal stream coding object location and body movements guides two decades of research in perception and action. A number of lines of evidence, including work from our laboratory, suggest that the model requires refinement. This work described in this proposal has two general aims. The first is to develop a model of the action system within a computational framework. The model includes two anatomically and functionally distinct components: the action representation system, mediated by the inferior parietal lobe, and the action execution system, mediated by dorsal stream structures in fronto-parietal cortex. The second general aim is to reconcile a major clinical syndrome, ideomotor apraxia (IM), with recent advances in the cognitive neuroscientific study of action. There are four specific aims. First, we will relate the diverse presentation of IM to the two components of the action system by evaluating a two-subtype model of lM. Second, through study of patients with IM, we will assess the distinction between two types of spatial coding of body position and body movement information. Third, we will assess the roles of objects in performing skilled movements, and the distinctions between object representations used in different contexts. Finally, we will elucidate internal models of movement used in programming actions. The proposed program of research is expected to continue to contribute to our understanding of the relationship of distinct representational and dynamic processing modules in normal and disordered action, and the neuroanatomic substrate for these processes. In addition, it is expected to significantly advance our understanding of lM, a common clinical disorder whose presentation, subtypes, and neuroanatomic substrate remain poorly understood.