DNA Nanodevices: Ligand-induced photocontrol of G-quadruplex structure as a therapeutic tool

用于DNA光调节的光响应配体的合成对于许多生物医学应用具有重要意义。本项目的目的是创造一类新的配体，这些配体可以特异性地和可逆地与DNA序列相互作用，以作为外部光刺激来调节构象和功能。这些新的配体与DNA的结合将通过各种技术（qPCR，UV，荧光，CD，NMR和分子模拟）进行测试。这些配体的生物活性也将用一组癌细胞和寄生虫菌株进行测试。

The synthesis of light responsive ligands for the photoregulation of DNA is of great importance for a number of biomedical applications. The aim of this project is to create a new classes of ligands that can interact specifically and reversibly with DNA sequences to modulate conformation and function using as an external light stimuli.The binding of these novel ligands to DNA will be tested with a variety of techniques (qPCR, UV, fluorescence, CD, NMR and molecular modelling. The biological activity of these ligands will also be tested with a panel of cancer cells and parasite strains.