DNA Nanodevices: Ligand-induced photocontrol of G-quadruplex structure as a therapeutic tool

DNA 纳米器件：配体诱导的 G-四链体结构光控制作为治疗工具

• 批准号: 2278741
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2278741
• 关键词: DNA; Nanodevices; Ligand; induced; photocontrol

The synthesis of light responsive ligands for the photoregulation of DNA is of great importance for a number of biomedical applications. The aim of this project is to create a new classes of ligands that can interact specifically and reversibly with DNA sequences to modulate conformation and function using as an external light stimuli.The binding of these novel ligands to DNA will be tested with a variety of techniques (qPCR, UV, fluorescence, CD, NMR and molecular modelling. The biological activity of these ligands will also be tested with a panel of cancer cells and parasite strains.

光响应配体的合成对DNA的光调节具有重要的生物医学应用价值。本项目的目的是创造一类新的配体，这些配体可以与DNA序列特异性地和可逆地相互作用，以调节构象和功能，利用外部光刺激，这些新的配体与DNA的结合将通过各种技术(qPCR，UV，荧光，CD，核磁共振和分子模拟)进行测试。这些配体的生物活性也将用一组癌细胞和寄生虫菌株进行测试。