Yeast Histone Acetylases and Sir2-like Deacetylases
Yeast Histone Acetylases and Sir2-like Deacetylases
批准号:
6730531
负责人:
Rolf Sternglanz
金额:
$25.59万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-05-01 至 2005-06-30
关键词:
Saccharomyces cerevisiaeacetylationacyltransferaseamidohydrolaseschromatinenzyme activityenzyme mechanismfungal geneticsfungal proteinsgene induction /repressiongene mutationhigh performance liquid chromatographyhistonesimmunoprecipitationmass spectrometrymolecular cloningprotein structure functiontemperature sensitive mutant
中文摘要
描述(来自申请人摘要的逐字逐句):
本研究旨在了解组蛋白乙酰化的作用,
染色质结构和功能的脱乙酰化,使用酵母
酿酒酵母来研究这些过程。因为许多酵母
参与乙酰化/脱乙酰化的蛋白质具有人类同源物,
该项目应该揭示人类生物学和疾病。具体目标为
这一时期是:1)了解Sir 2的酶机制和相关的
蛋白质,最近被证明是NAD依赖性蛋白质脱乙酰酶,2)
确定Sir 2在转录沉默中的作用是否是组蛋白
脱乙酰化,3)确定酵母Sir 2同源物的体内作用
Hst 2、Hst 3和Hst 4,4)了解蛋白质SUM 1 -1和Hst 1如何
在Sir 2不存在的情况下沉默交配型基因座HML和HMR,和5)
证明酵母蛋白Sas 2和SptlO是乙酰转移酶,
为了确定它们的底物是组蛋白还是其他蛋白质,
英文摘要
DESCRIPTION (Verbatim from the applicant's abstract): The long term goal of
this research is to understand the role of histone acetylation and
deacetylation in chromatin structure and function, using the yeast
Saccharomyces cerevisiae to study these processes. Since many of the yeast
proteins involved in acetylation/deacetylation have human homologs, this
project should shed light on human biology and disease. The specific aims for
this period are: 1) to learn about the enzymatic mechanism of Sir2 and related
proteins, recently demonstrated to be NAD-dependent protein deacetylases, 2) to
determine if the role of Sir2 in transcriptional silencing is histone
deacetylation, 3) to determine the in vivo roles of the yeast Sir2 homologs
Hst2, Hst3 and Hst4, 4) to understand how the proteins SUM1-1 and Hstl can
silence the mating type loci, HML and HMR, in the absence of Sir2, and 5) to
demonstrate that the yeast proteins Sas2 and SptlO are acetyltransferases and
to determine if their substrates are histones or other proteins,
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Histone Modifying Enzymes and Transcription
-
批准号:7898288
-
项目类别:
-
资助金额:$15.53万
-
财政年份:2009
-
负责人:Rolf Sternglanz
-
依托单位:
YEAST HISTONE ACETYLATION GENES AND MUTANTS
-
批准号:6180701
-
项目类别:
-
资助金额:$18.43万
-
财政年份:1997
-
负责人:Rolf Sternglanz
-
依托单位:
Histone Modifying Enzymes and Transcription
-
批准号:7244367
-
项目类别:
-
资助金额:$29.11万
-
财政年份:1997
-
负责人:Rolf Sternglanz
-
依托单位:
Yeast Histone Acetylases and Sir2-like Deacetylases
-
批准号:6636230
-
项目类别:
-
资助金额:$25.59万
-
财政年份:1997
-
负责人:Rolf Sternglanz
-
依托单位:
Yeast Histone Acetylases and Sir2-like Deacetylases
-
批准号:6331573
-
项目类别:
-
资助金额:$28.36万
-
财政年份:1997
-
负责人:Rolf Sternglanz
-
依托单位:
Histone Modifying Enzymes and Transcription
-
批准号:6989151
-
项目类别:
-
资助金额:$29.76万
-
财政年份:1997
-
负责人:Rolf Sternglanz
-
依托单位:
YEAST HISTONE ACETYLATION GENES AND MUTANTS
-
批准号:2701819
-
项目类别:
-
资助金额:$17.92万
-
财政年份:1997
-
负责人:Rolf Sternglanz
-
依托单位:
YEAST HISTONE ACETYLATION GENES AND MUTANTS
-
批准号:2024195
-
项目类别:
-
资助金额:$17.65万
-
财政年份:1997
-
负责人:Rolf Sternglanz
-
依托单位:
Yeast Histone Acetylases and Sir2-like Deacetylases
-
批准号:6519808
-
项目类别:
-
资助金额:$25.59万
-
财政年份:1997
-
负责人:Rolf Sternglanz
-
依托单位:
Histone Modifying Enzymes and Transcription
-
批准号:7442119
-
项目类别:
-
资助金额:$29.11万
-
财政年份:1997
-
负责人:Rolf Sternglanz
-
依托单位:
Histone Modifying Enzymes and Transcription
-
批准号:7082221
-
项目类别:
-
资助金额:$29.98万
-
财政年份:1997
-
负责人:Rolf Sternglanz
-
依托单位:
YEAST HISTONE ACETYLATION GENES AND MUTANTS
-
批准号:2910309
-
项目类别:
-
资助金额:$17.91万
-
财政年份:1997
-
负责人:Rolf Sternglanz
-
依托单位:
DNA TOPOISOMERASES AND OTHER ENZYMES AFFECTING CHROMATIN
-
批准号:2444505
-
项目类别:
-
资助金额:$34.78万
-
财政年份:1980
-
负责人:Rolf Sternglanz
-
依托单位:
DNA TOPOISOMERASES AND OTHER ENZYMES AFFECTING CHROMATIN
-
批准号:2175133
-
项目类别:
-
资助金额:$34.03万
-
财政年份:1980
-
负责人:Rolf Sternglanz
-
依托单位:
PROTEINS AND ENZYMES AFFECTING CHROMATIN
-
批准号:2910059
-
项目类别:
-
资助金额:$31.15万
-
财政年份:1980
-
负责人:Rolf Sternglanz
-
依托单位:
DNA TOPOISOMERASES AND OTHER ENZYMES AFFECTING CHROMATIN
-
批准号:3275510
-
项目类别:
-
资助金额:$17.39万
-
财政年份:1980
-
负责人:Rolf Sternglanz
-
依托单位:
DNA TOPOISOMERASES AND OTHER ENZYMES AFFECTING CHROMATIN
-
批准号:3275507
-
项目类别:
-
资助金额:$14.84万
-
财政年份:1980
-
负责人:Rolf Sternglanz
-
依托单位:
DNA TOPOISOMERASES AND OTHER ENZYMES AFFECTING CHROMATIN
-
批准号:3275505
-
项目类别:
-
资助金额:$19.47万
-
财政年份:1980
-
负责人:Rolf Sternglanz
-
依托单位:
Proteins and Enzymes Affecting Chromatin
-
批准号:6768596
-
项目类别:
-
资助金额:$36.87万
-
财政年份:1980
-
负责人:Rolf Sternglanz
-
依托单位:
DNA TOPOISOMERASES AND OTHER ENZYMES AFFECTING CHROMATIN
-
批准号:3275504
-
项目类别:
-
资助金额:$12.79万
-
财政年份:1980
-
负责人:Rolf Sternglanz
-
依托单位:
国内基金
海外基金
海马神经元胆固醇代谢重编程致染色质组蛋白乙酰化水平降低介导老年小鼠术后认知功能障碍
-
批准号:82371192
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:田婕
-
依托单位:
HK2乳酰化修饰介导巨噬细胞功能障碍在脓毒症中的作用及机制
-
批准号:82372160
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:陈峰
-
依托单位:
组蛋白乙酰化修饰ATG13激活自噬在牵张应力介导骨缝Gli1+干细胞成骨中的机制研究
-
批准号:82370988
-
项目类别:面上项目
-
资助金额:48.00万元
-
批准年份:2023
-
负责人:经典
-
依托单位: