Chinese Red Yeast Rice Comparison to Lovastatin

中国红曲米与洛伐他汀的比较

• 批准号: 6666250
• 负责人: David Heber
• 金额: $ 15.92万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6666250
• 关键词: alternative medicine; antiatherogenic agent; antihypercholesterolemic agent; clinical research; drug discovery /isolation; drug screening /evaluation; genetic transcription; genetically modified animals; human subject; laboratory mouse; lovastatin; male; oxoacid lyase; pharmacokinetics; plant extracts; rice; tissue /cell culture; yeasts

Description: This project will evaluate the effect, on cholesterol biosynthesis and atherosclerotic lesion formation, of a mixture of monacolins isolated from a yeast fermented rice compared to Lovastatin. This will be accomplished by measuring up-regulation of HMG-COA gene transcription in HEPG2 cell constructs containing a luciferase reporter gene. A second end point will be the formation of atherosclerotic lesions and measuring blood cholesterol levels in ApoE knockout mice. The final study will assay the bioavailability of the mixture of monacolins from red yeast rice and of pure Lovastatin in human volunteers.

描述：本项目将评估对胆固醇生物合成的影响 和动脉粥样硬化病变形成，分离自 一种酵母发酵的大米与洛伐他汀相比。这将通过 测量HEPG 2细胞构建体中HMG-COA基因转录的上调 含有荧光素酶报告基因。第二个终点将是编队 动脉粥样硬化病变和测量血液胆固醇水平在ApoE 敲除小鼠最后的研究将测定混合物的生物利用度， 从红曲米和纯洛伐他汀在人类志愿者的monacolins。