UCLA CENTER FOR DIETARY SUPPLEMENTS RESEARCH: BOTANICALS

这项申请建议建立加州大学洛杉矶分校膳食补充剂研究中心：植物药(CDSRB)，以促进跨学科研究，开发对植物膳食补充剂安全性和有效性的系统评估。我们已经在加州大学洛杉矶分校人类营养中心为拟议的CDSRB汇集了所需的多学科科学专业知识。为了实现以下具体目标：1)鉴定、鉴定和鉴定拟用作膳食补充剂或已作为膳食补充剂出售的植物药；2)评估植物成分的生物利用度和生物活性，包括植物化学标志物和/或可疑或已知的活性成分；3)确定植物药中的活性成分，并探索其在定义明确的生物系统中的作用机制；4)在细胞培养和动物实验中进行临床前研究；以及5)进行植物药的第一阶段和/或第二阶段临床评估。加州大学洛杉矶分校CHN CDSRB将满足对植物成分(包括明确定义的生物系统中的植物化学标记化合物和/或生物活性成分)的生物利用度和生物活性进行额外基础和临床研究的迫切需要，然后将在动物身上进行临床前研究，并对植物药进行临床I期和/或II期评估。在本申请中，我们概述了三个成熟的R01研究项目(中国红曲大米、绿茶和圣约翰麦芽汁)，四个试点研究(紫锥菊、类黄酮类、大豆异黄酮和植物雌激素)，以及农业和植物学、分析植物化学和生物统计学/临床药理学的三个科学核心。行政和规划核心将管理整个CDSRB、新调查员奖和试点研究方案支助培训和教育举措，这些举措将开始解决上述许多问题。加州大学洛杉矶分校医学院是美国十大生物医学研究机构之一，将提供丰富的跨学科环境，在这里可以实现拟议的植物学膳食补充剂研究中心的主要使命。

This application proposes to establish the UCLA Center for Dietary Supplements Research: Botanicals (CDSRB) in order to foster interdisciplinary research to develop systematic evaluation of the safety and efficacy of botanical dietary supplements. We have assembled the multi-disciplinary scientific expertise required for the proposed CDSRB at the UCLA Center for Human Nutrition. to accomplish the following specific aims: 1) Identify, characterize and authenticate botanicals intended for use as dietary supplements or already being sold as dietary supplements; 2) Assess the bioavailability and bioactivity of botanical ingredients including phytochemical marker compounds and/or suspected or known active ingredients; 3) Identify active constituents in botanicals and explore their mechanisms of action in well-defined biological systems; 4) Conduct pre-clinical studies in cell culture and in animals; and 5) Conduct phase I and/or II clinical evaluations of botanicals. The UCLA CHN CDSRB will fulfill the critical need for additional basic and clinical research on the bioavailability and bioactivity of botanical ingredients, including phytochemical marker compounds and/or biologically active constituents in well-defined biological systems and will then conduct pre-clinical studies in animals and clinical phase I and/or II evaluations of botanicals. In this application we outline three well developed R01 Research Projects (Chinese Red Yeast Rice, Green Tea, and St. John's Wort), four Pilot Studies (Echinacea, Flavonoids, Soy Isoflavones, and Plant Phytoestrogens, and three Scientific Cores in Agriculture and Botany, Analytic Phytochemistry, and Biostatistics/Clinical Pharmacology. An Administrative and Planning Core will administer the overall CDSRB, a New Investigator Award and Pilot Study Program support training and educational initiatives which will begin to address many of the issues outlined above. The UCLA School of Medicine is one of the top ten biomedical research institutions in the United States and will provide a rich interdisciplinary environment where the primary mission of the proposed Dietary Supplements Research Center in Botanicals can be achieved.