Efficient Polyether Synthesis Based on Apparent and Latent Symmetry

基于表观对称和潜对称的高效聚醚合成

• 批准号: 2279910
• 金额: --
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2279910
• 关键词: Efficient; Polyether; Synthesis; Based; Apparent

The project will involve the development of a new, highly efficient and general method for the synthesis of structurally complex fused polycyclic ether natural products of marine origin. Natural product sub-units bearing apparent or latent symmetry will identified and the unique properties of centrosymmetric systems will exploited to prepare these systems rapidly. The rapid and efficient synthesis of bicyclic or tetracyclic centrosymmetric systems and their subsequent asymmetric desymmetrisation using chiral reagents will be explored. Synthesis of representative key fragments of marine polyether natural products using bidirectional methods will be attempted thereafter.

该项目将涉及开发一种新的、高效和通用的方法，用于合成海洋来源的结构复杂的稠合多环醚天然产物。将识别具有明显或潜在对称性的自然积亚单位，并将利用中心对称系统的独特性质来快速制备这些系统。将探索快速有效地合成双环或四环中心对称体系，以及随后使用手性试剂进行的不对称去对称化。此后将尝试使用双向方法合成具有代表性的海洋聚醚天然产物的关键片段。