Efficient Polyether Synthesis Based on Apparent and Latent Symmetry

基于表观对称和潜对称的高效聚醚合成

• 批准号: 2279910
• 金额: --
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2279910
• 关键词: Efficient; Polyether; Synthesis; Based; Apparent

The project will involve the development of a new, highly efficient and general method for the synthesis of structurally complex fused polycyclic ether natural products of marine origin. Natural product sub-units bearing apparent or latent symmetry will identified and the unique properties of centrosymmetric systems will exploited to prepare these systems rapidly. The rapid and efficient synthesis of bicyclic or tetracyclic centrosymmetric systems and their subsequent asymmetric desymmetrisation using chiral reagents will be explored. Synthesis of representative key fragments of marine polyether natural products using bidirectional methods will be attempted thereafter.

该项目将涉及开发一种新的，高效且一般的方法，用于合成海洋来源的结构复杂的融合多环天然产物。具有明显或潜在对称性的天然产品子单元将确定，并且将利用中心对称系统的独特性能来快速准备这些系统。将探索使用手性试剂的双环或四环中心对称系统的快速有效合成及其随后的非对称降压。此后将尝试使用双向方法合成海洋多醚生产产物的代表性关键片段。