Mechanisms Regulating Germline Stem Cells in Drosophila
果蝇生殖干细胞的调节机制
基本信息
- 批准号:6689556
- 负责人:
- 金额:$ 22.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-01-01 至 2006-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Adult stem cells can renew themselves at
each division and generate terminally differentiated progeny that maintain
homeostasis in adult tissues. A major issue in understanding adult stem cells
has been to distinguish whether regulation is primarily controlled by internal
or external mechanisms. In mammalian systems, stromal cells have been
hypothesized to form special microenvironments or niches for stem cells. Due to
the difficulty in identifying stem cells and surrounding stem cells in vivo,
there is little known about the structure and function of stem cell niches.
Recently, we have demonstrated the existence of germline stem cell (GSC) niches
in the Drosophila ovary, where stem cells and their surrounding cells can be
effectively studied in vivo. We have also identified decapentaplegic (dpp),
encoding a TGF-beta-like growth factor, as a key signal from the niche cells
regulating GSC self-renewal and division. However, there are still many
questions that remain to be answered regarding how the niche regulates GSCs.
The long-term goal of this project will be to gain a greater understanding of
how the niches regulate stem cells, and of dpp and other signaling pathways
involved in the communication between stem cells and their niches, and of
intrinsic factors in stem cells that interpret these signals. We will focus on
how the dpp pathway regulates GSC self-renewal and differentiation. Our genetic
screens have identified mutants that affect GSC self-renewal and
differentiation. Further molecular characterization of some of these mutants
will reveal important molecular mechanisms regulating GSCs. The mechanisms
controlling GSCs in the Drosophila ovary are likely to be fundamental to the
understanding of adult mammalian stem cells since stem cells from diverse
organisms share similar "stem" properties. In addition, a better understanding
of the mechanisms regulating stem cells is of considerable clinical relevance,
since the pathways and genes involved will provide valuable information for
using stem cells clinically and for treating some degenerative diseases and
cancer.
描述(由申请人提供):成体干细胞可以自我更新,
每次分裂并产生终末分化的后代,
体内平衡。了解成体干细胞的主要问题
一直是区分监管是否主要由内部控制,
或外部机制。在哺乳动物系统中,
假设为干细胞形成特殊的微环境或小生境。由于
在体内识别干细胞和周围干细胞的困难,
对干细胞小生境的结构和功能知之甚少。
最近,我们已经证明了生殖系干细胞(GSC)龛的存在
在果蝇的卵巢中,干细胞和它们周围的细胞可以
在体内进行有效研究。我们还发现了十肢瘫痪(dpp),
编码TGF-β样生长因子,作为来自小生境细胞的关键信号,
调节GSC自我更新和分裂。但仍有不少
关于生态位如何调节GSC的问题仍然有待回答。
该项目的长期目标是更好地了解
小生境如何调节干细胞,以及DPP和其他信号通路
参与干细胞和它们的小生境之间的交流,
干细胞中的内在因子来解释这些信号。我们将专注于
DPP途径如何调节GSC自我更新和分化。我们的遗传
筛选已经鉴定出影响GSC自我更新的突变体,
分化对其中一些突变体的进一步分子表征
将揭示调控GSC的重要分子机制。的机制
控制果蝇卵巢中的GSC可能是
成体哺乳动物干细胞的理解,因为干细胞来自不同的
生物体具有相似的“茎”特性。此外,更好地了解
调节干细胞的机制具有相当大的临床意义,
因为所涉及的途径和基因将为
干细胞在临床上的应用以及治疗一些退行性疾病,
癌
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('TING XIE', 18)}}的其他基金
Investigation of Niche Control of Germline Stem Cell Lineage Differentiation
生殖干细胞谱系分化的生态位控制研究
- 批准号:
9906238 - 财政年份:2019
- 资助金额:
$ 22.26万 - 项目类别:
Investigation of Notch signaling in the regulation of ciliary body development and function
Notch信号在睫状体发育和功能调节中的研究
- 批准号:
9220447 - 财政年份:2017
- 资助金额:
$ 22.26万 - 项目类别:
Molecular Mechanisms Regulating Drosophila Ovarian Germline Stem Cells
调节果蝇卵巢生殖干细胞的分子机制
- 批准号:
7201929 - 财政年份:2002
- 资助金额:
$ 22.26万 - 项目类别:
Molecular Mechanisms Regulating Drosophila Ovarian Germline Stem Cells
调节果蝇卵巢生殖干细胞的分子机制
- 批准号:
7333264 - 财政年份:2002
- 资助金额:
$ 22.26万 - 项目类别:
Mechanisms Regulating Germline Stem Cells in Drosophila
果蝇生殖干细胞的调节机制
- 批准号:
6835207 - 财政年份:2002
- 资助金额:
$ 22.26万 - 项目类别:
Mechanisms Regulating Germline Stem Cells in Drosophila
果蝇生殖干细胞的调节机制
- 批准号:
6416428 - 财政年份:2002
- 资助金额:
$ 22.26万 - 项目类别:
Mechanisms Regulating Germline Stem Cells in Drosophila
果蝇生殖干细胞的调节机制
- 批准号:
6620370 - 财政年份:2002
- 资助金额:
$ 22.26万 - 项目类别:
Molecular Mechanisms Regulating Drosophila Ovarian Germline Stem Cells
调节果蝇卵巢生殖干细胞的分子机制
- 批准号:
7544918 - 财政年份:2002
- 资助金额:
$ 22.26万 - 项目类别:
Mechanisms Regulating Germline Stem Cells in Drosophila
果蝇生殖干细胞的调节机制
- 批准号:
6993650 - 财政年份:2002
- 资助金额:
$ 22.26万 - 项目类别:
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