Cell and Process Engineering for Recombinant Antibody Production

重组抗体生产的细胞和工艺工程

• 批准号: 2280355
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2280355
• 关键词: Cell; Process; Engineering; Recombinant; Antibody

A vast expansion in the number of recombinant protein therapeutics in development, with a diversification in their molecular architecture necessitates the development of cell and process engineering technologies that can both rapidly generate product and improve manufacturability. This project will harness significant expertise at both The University of Sheffield and Absolute Antibody Ltd. to create new transient bioproduction systems for cost-effective and scalable production of diverse recombinant proteins in mammalian cells. Core, novel technological innovation will occur at Sheffield and then be translated into commercial practice at Absolute Antibody (https://absoluteantibody.com). This project therefore represents an excellent opportunity for a postgraduate student to receive training in world-leading R&D for biomanufacturing with the opportunity to reduce this to core commercial practice in a rapidly expanding SME based in the N8 region.

随着分子结构的多样化，正在开发的重组蛋白疗法数量的大量增加，需要细胞和工艺工程技术的发展，这些技术既可以快速产生产品，又可以提高可制造性。该项目将利用谢菲尔德大学和绝对抗体有限公司的重要专业知识，创建新的瞬态生物生产系统，用于在哺乳动物细胞中经济高效地、可扩展地生产多种重组蛋白。核心的、新颖的技术创新将在谢菲尔德大学出现，然后在Absolute Antibody （https://absoluteantibody.com）转化为商业实践。因此，该项目为研究生提供了一个极好的机会，可以接受世界领先的生物制造研发培训，并有机会将其转化为N8地区快速扩张的中小企业的核心商业实践。