Leishmania Antigen Presentation by Infected Cells

描述（由申请方提供）：利什曼病是一种重要的人类和动物疾病，在全球范围内分布，包括北美，最近报告了野狗的内源性传播。该疾病表现为一系列表现，可累及皮肤和多个内脏器官。它是慢性的，并表现出自发缓解的趋势。这些寄生虫感染的免疫学研究提供了有价值的见解功能性T细胞的发展，在抗原活化。然而，有趣的是，即使在对寄生虫的应答中引起强烈的宿主免疫应答，利什曼原虫在受感染的宿主中持续存在。这表明寄生虫已经进化出一种逃避免疫检测的策略。这项研究提出，利什曼原虫无鞭毛体损害感染的巨噬细胞的能力，处理和目前的寄生虫分子的CD4+ T细胞。阐明这一过程的潜在机制的方法是建立在吞噬受体作为L。墨西哥模式。具体而言，研究确定了寄生虫通过Fc或补体受体内化时寄生虫空泡内容物的演变。当空泡允许抗原呈递时，存在的主要空泡特征应该容易辨别。这些研究将揭示寄生虫的过程，可以针对控制利什曼原虫

DESCRIPTION (provided by the applicant): Leishmaniasis is an important human and animal disease with a worldwide distribution including in North America where endogenous transmission in wild dogs has recently been reported. The disease presents as a spectrum of manifestations that can involve the skin and multiple visceral organs. It is chronic and exhibits a tendency for spontaneous remission. Immunological studies of infections by these parasites have provided valuable insights into functional T cell development in response to antigen activation. It is however intriguing that even though vigorous host immune responses are elicited in response to the parasite, Leishmania persist in the infected host. This suggests that the parasites have evolved a strategy to evade immune detection. This study proposes that Leishmania amastigotes impair the ability of infected macrophages to process and present parasite molecules to CD4+ T cells. The approach to elucidate the underlying mechanism of this process builds on observations that implicated the phagocytic receptor as a determinant of pathogenesis in the L. mexicana model. Specifically, studies ascertain the evolution of the contents of the parasitophorous vacuole when parasites are internalized through the Fc or complement receptors. The prevailing vacuole characteristics that exist when the vacuole is permissive of antigen presentation should be readily discerned. These studies will expose parasite processes that can be targeted for the control of Leishmania