Leishmania Antigen Presentation by Infected Cells

利什曼病是一种重要的人畜共患疾病，在世界范围内均有分布，其中北方的 美国，最近有报道野狗的内源性传播。该病表现为 一系列的表现，可以涉及皮肤和多个内脏器官。它是慢性的， 自然缓解的趋势对这些寄生虫感染的免疫学研究提供了 对响应抗原激活的功能性T细胞发育的宝贵见解。然而， 尽管宿主对利什曼原虫的免疫反应很强， 在被感染的宿主体内持续存在。这表明这些寄生虫已经进化出一种逃避免疫的策略， 这项研究表明，利什曼原虫无鞭毛体损害感染的巨噬细胞的能力， 处理并将寄生虫分子呈递给CD4+ T细胞。阐明潜在的 这一过程的机制建立在吞噬细胞受体作为决定因素的观察基础上 致病机理的研究。墨西哥模式。具体而言，研究确定了 当寄生虫通过Fc或补体受体被内化时，寄生虫泡。的 当空泡允许抗原呈递时存在的主要空泡特征应该 很容易辨别。这些研究将揭示寄生虫的过程，可以有针对性地控制 Leishmania

Leishmaniasis is an important human and animal disease with a worldwide distribution including in North America where endogenous transmission in wild dogs has recently been reported. The disease presents as a spectrum of manifestations that can involve the skin and multiple visceral organs. It is chronic and exhibits a tendency for spontaneous remission. Immunological studies of infections by these parasites have provided valuable insights into functional T cell development in response to antigen activation. It is however intriguing that even though vigorous host immune responses are elicited in response to the parasite, Leishmania persist in the infected host. This suggests that the these parasites have evolved a strategy to evade immune detection.This study proposes that Leishmania amastigotes impair the ability of infected macrophages to process and present parasite molecules to CD4+ T cells. The approach to elucidate the underlying mechanism of this process builds on observations that implicated the phagocytic receptor as a determinant of pathogenesis in the L. mexicana model. Specifically, studies ascertain the evolution of the contents of the parasitophorous vacuole when parasites are internalized through the Fc or complement receptors. The prevailing vacuole characteristerics that exist when the vacuole is permissive of antigen presentation should be readily discerned. These studies will expose parasite processes that can be targeted for the control of Leishmania