Regulation of Skilled Movements by Subcortical Basal Ganglia and Cerebellar Loops

皮层下基底神经节和小脑环对熟练运动的调节

• 批准号: 6703619
• 负责人: JAMES C HOUK
• 金额: $ 17.75万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6703619
• 关键词: apraxias; basal ganglia; behavior test; body movement; cerebellum; frontal lobe /cortex; human subject; magnetoencephalography; musculoskeletal system; neuromuscular system; psychomotor function

The long-term goal of this research is to elucidate the dynamic brain mechanisms underlying spatio-temporally integrated motor and cognitive tasks using magetoencephalography (MEG). The tasks are designed to test hypotheses regarding temporal integration of information as the tasks are being carried out in space. We will focus on praxis, namely complex, purposeful motor actions, such as copying figures from visual templates and finding exist routes in mazes. These tasks are commonly used in clinical neurology underlying these tasks require planning across, and unfold within, space and time, and therefore, exemplify the theme of this program project research application. Data will be acquired using a state-of-the-art whole-head MEG instrument with 248 axial gradiometers. The hypotheses will be tested (a) that specific praxis tasks involve cooperative interactions of specific brain areas, especially in the parietal and frontal cortex, (b) that there is a partial overlap among the dynamic patterns of this activation across tasks, and (c) that this overlap corresponds to the common functional core shared by these tasks. The dynamic processing aspects of the core as well as signal analysis of individual MEG channels and their relations. A 64-processor Linux cluster will be used for these analyses. The results to be obtained will provide novel insights into how the brain deals with dynamic spatiotemporal processes and carries out purposeful eupractic motor actions. It is expected that these insights will lead, in turn, to the generation of specific hypotheses concerning altered neural mechanisms underlying constructional apraxia.

本研究的长期目标是利用脑磁图(MEG)阐明时空整合运动和认知任务背后的动态脑机制。这些任务旨在测试有关在太空中执行任务时信息的时间整合的假设。我们将专注于实践，即复杂的、有目的的运动动作，如从视觉模板复制图形和在迷宫中寻找现有路线。这些任务通常用于临床神经学，这些任务需要跨空间和时间进行规划，并在其中展开，因此，例证了本计划项目研究应用的主题。数据将使用最先进的带有248个轴向梯度计的全头脑磁图仪器采集。这些假设将被检验：(A)特定的实践任务涉及特定大脑区域的合作互动，特别是在顶叶和额叶皮质；(B)不同任务之间这种激活的动态模式存在部分重叠；以及(C)这种重叠对应于这些任务共享的共同功能核心。核心的动态处理方面，以及各个脑磁图通道的信号分析及其关系。这些分析将使用一个使用处理器的Linux集群。将获得的结果将为大脑如何处理动态的时空过程和执行有目的的最佳运动动作提供新的见解。预计这些洞察力将反过来导致关于结构性失用的神经机制改变的特定假说的产生。