Participation of the Cerebellum in Problem Solving

小脑参与解决问题

• 批准号: 6761789
• 负责人: JAMES C HOUK
• 金额: $ 31.06万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6761789
• 关键词: Macaca; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain mapping; cerebellum; cerebral cortex; clinical research; cognition; dentate nucleus; functional magnetic resonance imaging; histochemistry /cytochemistry; human subject; method development; problem solving

DESCRIPTION (provided by applicant): The network of investigators proposed here will explore how problem solving activities engage different loops and circuits that patch together channels through a cognitive map in the dentate nucleus of the cerebellum. Our proposed activities represent a unique focus on developing tasks and methods for cross-species comparisons, bridge building between anatomical and functional data, and joint consideration of both motor and cognitive functions of the cerebellum. Dr. Strick will generate plans for the construction of an unfolded map of the dentate projections to the cerebral cortex in non-human primates. Dr. Miller will generate plans to study how single unit activity is distributed across this map when monkeys engage in cognitive tasks. The PI, Dr. Houk, will explore conceptual and computational models of signal processing in the modular networks in which the dentate channels participate. Our consultant, Dr. Lewis, will work with Dr. Strick to develop correspondences between molecular staining of human and monkey dentate. Dr. Kim will develop high-resolution imaging methods for exploring human dentate. Drs. Fiez and Reber will formulate plans for using this constellation of tools to document the activation patterns that occur in the cerebellar dentate nucleus when humans are executing problem-solving tasks. Interactions with our consultant Dr. Mesulam will help us explore correlations with neurological disorders and the attentional network spread across the cerebral cortex. Similarly, interactions with Dr. Lewis will help us explore correlations with schizophrenia and other psychological disorders.

描述（由申请人提供）：这里提出的研究人员网络将探索解决问题的活动如何通过小脑齿状核中的认知地图将不同的回路和电路拼凑在一起。我们提出的活动代表了一个独特的重点发展的任务和方法，跨物种的比较，解剖和功能数据之间的桥梁建设，并共同考虑小脑的运动和认知功能。斯特里克博士将为构建非人类灵长类动物大脑皮层齿状突起的展开地图制定计划。米勒博士将制定计划，研究当猴子从事认知任务时，单个单位活动如何分布在这张地图上。PI Houk博士将探索齿状通道参与的模块化网络中信号处理的概念和计算模型。我们的顾问，刘易斯博士，将与斯特里克博士合作，开发人类和猴子齿状细胞分子染色之间的对应关系。Kim博士将开发用于探索人类牙齿的高分辨率成像方法。Fiez和Reber博士将制定计划，使用这些工具来记录人类执行解决问题任务时小脑齿状核中发生的激活模式。与我们的顾问Mesulam博士的互动将帮助我们探索神经系统疾病和大脑皮层中的注意力网络之间的相关性。同样，与刘易斯博士的互动将有助于我们探索精神分裂症和其他心理障碍的相关性。