Nebraska Redox Biology Center

内布拉斯加州氧化还原生物中心

• 批准号: 6665149
• 负责人: RUMA V BANERJEE
• 金额: $ 187.81万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6665149
• 关键词: cooperative study; health science research support; interdisciplinary collaboration; oxidation reduction reaction

DESCRIPTION (provided by applicant): This IDeA proposal presents a detailed plan to create a rnultidisciplinary Center for Biomedical Research Excellence (COBRE) in Nebraska for Redox Biology. The Center will link scientists at the two leading research-active institutions in the state - the UN-Lincoln and the UNMC - in a collaborative pursuit to unravel fundamental problems in redox biology that impact the pathogenesis of a number of diseases including some cancers, arthritis and cardiovascular diseases and the progression of natural phenomena such as aging. The objectives of the proposed Center are (i) to enhance biomedical research capacity in the state by creating an infrastructure that will strategically link strong research programs in redox biology at the two institutions and (ii) to mentor a cadre of junior faculty to independent funding success at NIH. These objectives will be met by providing a rich and rigorous mentoring environment for junior investigators, by bolstering core facilities, by fostering collaborations among scientists at both institutions and by recruiting five additional faculty members with research interests in the area of redox biology to ensure the critical mass of scientists necessary to sustain a nationally visible and internationally recognized Center. A key design feature for the organization of the Center is the mentoring of each of the five developing faculty members by an established investigator with similar research interests and a successful track record of funding at NIH. As these project leaders transition to funding independence, their projects will be replaced by ones led by the newly recruited faculty members. A Director with the vision, scientific expertise and administrative experience necessary to provide effective leadership will be primarily responsible for steering the Center. She will be counseled by members of the Mentoring Council, comprising five established scientists at the Nebraska institutions, and guided by an External Advisory Council (EAC) comprising eight outstanding scientists, five of whom are members of the National Academy of Sciences, and all of whom have agreed to serve in this capacity. The synergistic environment resulting from the creation of the Center will enrich the culture of research in the state, will enliven its community of biomedical scientists and will elevate the quality and offerings of key core facilities.

描述（由申请人提供）：该 IDeA 提案提出了在内布拉斯加州创建氧化还原生物学多学科生物医学卓越研究中心 (COBRE) 的详细计划。该中心将联合该州两个领先的研究活跃机构——联合国林肯分校和内华达大学医学中心——的科学家，共同努力解决氧化还原生物学中的基本问题，这些问题影响包括一些癌症、关节炎和心血管疾病在内的多种疾病的发病机制，以及衰老等自然现象的进展。拟议中心的目标是（i）通过创建一个基础设施来增强该州的生物医学研究能力，该基础设施将战略性地连接两个机构在氧化还原生物学方面的强大研究项目，以及（ii）指导一批初级教师在 NIH 取得独立资助的成功。 这些目标将通过以下方式实现：为初级研究人员提供丰富而严格的指导环境，加强核心设施，促进两个机构科学家之间的合作，并招募五名对氧化还原生物学领域有研究兴趣的额外教员，以确保维持一个全国知名和国际认可的中心所需的关键科学家数量。该中心组织的一个关键设计特点是，五位发展中的教员中的每一位都由一位具有相似研究兴趣且在 NIH 拥有成功资助记录的资深研究员进行指导。随着这些项目负责人过渡到资金独立，他们的项目将被新招募的教员领导的项目所取代。一名具有有效领导所需的远见、科学专业知识和行政经验的主任将主要负责指导该中心。她将接受由内布拉斯加州机构的五名知名科学家组成的指导委员会成员的咨询，并由八名杰出科学家组成的外部咨询委员会（EAC）提供指导，其中五名是美国国家科学院院士，他们都同意担任这一职务。 该中心的创建所产生的协同环境将丰富该州的研究文化，活跃其生物医学科学家群体，并将提高关键核心设施的质量和产品。