A COBRE CENTER FOR CARDIOVASCULAR RESEARCH

描述(由申请者提供)：本公司的总体目标 首创计划是在伦敦建立一个心血管研究中心 夏威夷大学(UH)。 这项建议是建立在几个令人振奋的新发展之上的 在过去的四年里，这所大学使这一倡议成为可能。 生物学，特别是心血管系统的病理生物学 是密歇根大学一个新兴的研究主题。由美国国立卫生研究院资助的首席调查人员 指导这些研究工作已经建立了一个跟踪记录 合作和为有前途的年轻教师提供有效的指导计划。 有了这个中心提案的资金，这些国家认可的 研究人员，具有分子和细胞生物学、生物化学和 遗传学，将有机会，在校长的指导下 研究人员，以扩展和加强他们当前的研究和指导 能力。这些目标将通过三个主要的具体目标来实现 目标： 1.建立一个由老牌调查人员组成的强大的指导小组， 具有跨学科但互补的血管和 心血管生物学，以支持选定的一组 很有前途的年轻调查员。 2.通过发展以下项目加强基础设施支持 实验室核心设施、行政支持和资源，以便 提高现有研究人员的研究竞争力和 年轻的教员。 3.制定一项战略计划，协助招聘和 留住有才华和资金的年轻教员和资深调查人员 在UH的教职员工职位上，以促进 心血管研究计划成为密歇根大学的一个主要研究学科 稳定的融资机会不仅是平行的，而且最终将取代 科布雷基金。

DESCRIPTION (provided by applicant): The overall goal of this COBRE initiative is to develop a Center for Cardiovascular Research at the University of Hawaii (UH). This proposal is built upon several exciting new developments at the University over the last four years that have made this initiative possible. The biology and particularly the pathobiology of the cardiovascular system has been an emerging research theme at UH. The NIH-funded principal investigators directing these research efforts have established a track record of collaboration and an effective mentoring program for promising young faculty. With funds from this center proposal, these nationally recognized investigators, with expertise in molecular and cell biology, biochemistry and genetics, would have the opportunity, under the direction of the Principal Investigator, to expand upon and enhance their current research and mentoring capabilities. These goals would be achieved through three primary specific aims: 1. The development of a strong mentoring group of established investigators, with interdisciplinary but complementary backgrounds in vascular and cardiovascular biology, to support the career growth of a selected group of promising young investigators. 2. The enhancement of infrastructure support through the development of laboratory core facilities, adminstrative support and resources, in order to increase the research competitiveness of both established investigators and young faculty. 3. The development of a strategic plan to assist in the recruitment and retention of talented and funded young faculty and established investigators in faculty positions at UH in order to promote the continued growth of a cardiovascular research program into a major research discipline at UH with stable funding opportunities to not only parallel but to eventually replace COBRE funding.