SOCIAL LEARNING AND ALCOHOL INTAKE IN ADOLESCENT RATS

青春期大鼠的社交学习和酒精摄入量

基本信息

  • 批准号:
    6752958
  • 负责人:
  • 金额:
    $ 9.27万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-06-01 至 2005-05-31
  • 项目状态:
    已结题

项目摘要

The age at which alcohol consumption by young adults begins is reported to be ever decreasing. Recent surveys indicate that over 10% of 13- year olds use alcohol and about 70% of high schoolers consume alcohol more than once per month. Of these individuals, nearly one-third report binge drinking (defined as consuming more than 5 drinks per occasion) on a weekly basis. In light of these astonishing statistics, our lack of understanding about the underlying causes of adolescent-onset drinking is surprising as well as disturbing. The largest amount of data on this topic has come from studies using selectively bred strains of rodents showing a clear genetic determinant of alcoholism. However, it is also recognized that genetics alone cannot account for the prevalence of alcohol abuse. Experiential factors must also act, either alone or in concert with genetic predisposition. Due to the early age of onset of alcohol consumption patterns, it is likely that experiences with alcohol occurring early in life contribute to later acceptance of this drug. The long-term objective of the proposed research plan is to understand more fully the mechanisms, behavioral and neurochemical, through which socially mediated increases in ethanol preferences are acquired by preweanling and periadolescent rats. The research will build upon a paradigm recently developed by the PI for rapidly inducing ethanol preferences in preweanling and periadolescent rats. Briefly, one animal (demonstrator) is intragastrically administered a dose of ethanol shortly before a 30-min period of behavioral interaction with the experimental subject (observer). In several experiments we have shown that observers subsequently increase their ethanol intake by up to 75-150% over control levels. Our working hypothesis is that observers detect respired ethanol cues on the breath of the demonstrator in the presence of an endogenous carbon based constituent of rat breath (carbon disulfide), and carbon disulfide promotes the release of endogenous opioids that serve functionally as the reinforcer for the conditioning of preferences for ethanol. To test this hypothesis, we will examine the role of endogenous opioids in promoting the increased ethanol intake patterns through pharmacologically manipulating primarily mu and kappa opioid receptors. The end result of this work will be an increased understanding of the neurochemical and behavioral factors underlying social acquisition of ethanol preferences.
年轻人开始饮酒的年龄是

项目成果

期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cholinergic modulation of trace conditioning trained in serial compound: A developmental analysis.
在系列化合物中训练的微量调节的胆碱能调节:发育分析。
  • DOI:
    10.1016/j.nlm.2006.05.001
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Hunt,PamelaS;Barnet,RobertC;Shea,MeghanE;Baker,EricM
  • 通讯作者:
    Baker,EricM
Intermittent ethanol exposure in adolescent rats: dose-dependent impairments in trace conditioning.
青春期大鼠间歇性乙醇暴露:微量调节的剂量依赖性损伤。
Postnatal ethanol exposure disrupts signal detection in adult rats.
出生后接触乙醇会扰乱成年大鼠的信号检测。
  • DOI:
    10.1016/j.ntt.2005.07.002
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Woolfrey,KevinM;Hunt,PamelaS;Burk,JoshuaA
  • 通讯作者:
    Burk,JoshuaA
Neonatal treatment with a competitive NMDA antagonist results in response-specific disruption of conditioned fear in preweanling rats.
使用竞争性 NMDA 拮抗剂进行新生儿治疗会导致断奶前大鼠条件性恐惧的反应特异性破坏。
  • DOI:
    10.1007/s00213-005-0291-1
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Hunt,PamelaS
  • 通讯作者:
    Hunt,PamelaS
Early postnatal ethanol administration does not affect prepulse inhibition in rats.
出生后早期施用乙醇不影响大鼠的前脉冲抑制。
  • DOI:
    10.1016/j.physbeh.2005.03.003
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Woolfrey,KevinM;Musisca,NicholasJ;Hunt,PamelaS;Burk,JoshuaA
  • 通讯作者:
    Burk,JoshuaA
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PAMELA S HUNT其他文献

PAMELA S HUNT的其他文献

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{{ truncateString('PAMELA S HUNT', 18)}}的其他基金

Mechanisms of Trace Fear Conditioning in the Developing Rat
发育中大鼠的微量恐惧调节机制
  • 批准号:
    8291269
  • 财政年份:
    2011
  • 资助金额:
    $ 9.27万
  • 项目类别:
Mechanisms of Trace Fear Conditioning in the Developing Rat
发育中大鼠的微量恐惧调节机制
  • 批准号:
    8206412
  • 财政年份:
    2011
  • 资助金额:
    $ 9.27万
  • 项目类别:
Neonatal Ethanol-Induced Memory Impairments in Rats
新生大鼠乙醇引起的记忆障碍
  • 批准号:
    6850358
  • 财政年份:
    2005
  • 资助金额:
    $ 9.27万
  • 项目类别:
Neonatal Ethanol-Induced Memory Impairments in Rats
新生大鼠乙醇引起的记忆障碍
  • 批准号:
    7227123
  • 财政年份:
    2005
  • 资助金额:
    $ 9.27万
  • 项目类别:
Neonatal Ethanol-Induced Memory Impairments in Rats
新生大鼠乙醇引起的记忆障碍
  • 批准号:
    7414385
  • 财政年份:
    2005
  • 资助金额:
    $ 9.27万
  • 项目类别:
Neonatal Ethanol-Induced Memory Impairments in Rats
新生大鼠乙醇引起的记忆障碍
  • 批准号:
    7058865
  • 财政年份:
    2005
  • 资助金额:
    $ 9.27万
  • 项目类别:
Neonatal Ethanol-Induced Memory Impairments in Rats
新生大鼠乙醇引起的记忆障碍
  • 批准号:
    7614358
  • 财政年份:
    2005
  • 资助金额:
    $ 9.27万
  • 项目类别:
SOCIAL LEARNING AND ALCOHOL INTAKE IN ADOLESCENT RATS
青春期大鼠的社交学习和酒精摄入量
  • 批准号:
    6371595
  • 财政年份:
    2000
  • 资助金额:
    $ 9.27万
  • 项目类别:
CHRONIC POSTNATAL ALCOHOL AND ATTENTION IN THE RAT
大鼠慢性产后酒精和注意力
  • 批准号:
    6040591
  • 财政年份:
    2000
  • 资助金额:
    $ 9.27万
  • 项目类别:
CHRONIC POSTNATAL ALCOHOL AND ATTENTION IN THE RAT
大鼠慢性产后酒精和注意力
  • 批准号:
    6371530
  • 财政年份:
    2000
  • 资助金额:
    $ 9.27万
  • 项目类别:
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