SOCIAL LEARNING AND ALCOHOL INTAKE IN ADOLESCENT RATS

青春期大鼠的社交学习和酒精摄入量

基本信息

  • 批准号:
    6752958
  • 负责人:
  • 金额:
    $ 9.27万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-06-01 至 2005-05-31
  • 项目状态:
    已结题

项目摘要

The age at which alcohol consumption by young adults begins is reported to be ever decreasing. Recent surveys indicate that over 10% of 13- year olds use alcohol and about 70% of high schoolers consume alcohol more than once per month. Of these individuals, nearly one-third report binge drinking (defined as consuming more than 5 drinks per occasion) on a weekly basis. In light of these astonishing statistics, our lack of understanding about the underlying causes of adolescent-onset drinking is surprising as well as disturbing. The largest amount of data on this topic has come from studies using selectively bred strains of rodents showing a clear genetic determinant of alcoholism. However, it is also recognized that genetics alone cannot account for the prevalence of alcohol abuse. Experiential factors must also act, either alone or in concert with genetic predisposition. Due to the early age of onset of alcohol consumption patterns, it is likely that experiences with alcohol occurring early in life contribute to later acceptance of this drug. The long-term objective of the proposed research plan is to understand more fully the mechanisms, behavioral and neurochemical, through which socially mediated increases in ethanol preferences are acquired by preweanling and periadolescent rats. The research will build upon a paradigm recently developed by the PI for rapidly inducing ethanol preferences in preweanling and periadolescent rats. Briefly, one animal (demonstrator) is intragastrically administered a dose of ethanol shortly before a 30-min period of behavioral interaction with the experimental subject (observer). In several experiments we have shown that observers subsequently increase their ethanol intake by up to 75-150% over control levels. Our working hypothesis is that observers detect respired ethanol cues on the breath of the demonstrator in the presence of an endogenous carbon based constituent of rat breath (carbon disulfide), and carbon disulfide promotes the release of endogenous opioids that serve functionally as the reinforcer for the conditioning of preferences for ethanol. To test this hypothesis, we will examine the role of endogenous opioids in promoting the increased ethanol intake patterns through pharmacologically manipulating primarily mu and kappa opioid receptors. The end result of this work will be an increased understanding of the neurochemical and behavioral factors underlying social acquisition of ethanol preferences.
年轻人开始饮酒的年龄是 据报道,它正在不断减少。 最近的调查显示,13- 20岁的孩子饮酒,大约70%的高中生饮酒更多 每月一次以上。 在这些人中,近三分之一的人报告说, 每周饮酒(定义为每次饮酒超过5杯) 基础 根据这些惊人的统计数据,我们缺乏了解 关于酗酒的潜在原因也令人惊讶 令人不安。 关于这一主题的最大数量的数据来自研究 使用选择性繁殖的啮齿动物品系, 酒精中毒 然而,人们也认识到, 导致了酗酒的流行 经验因素也必须 行为,无论是单独或与遗传易感性。 由于提前 酒精消费模式的发病年龄,很可能是经验, 与酒精发生在生命的早期有助于后来接受这一点 药 拟议研究计划的长期目标是了解更多 完全的机制,行为和神经化学,通过社会 通过断奶前获得乙醇偏好的介导增加, 青春期大鼠这项研究将建立在最近的一个范例之上 由PI开发,用于在断奶前快速诱导乙醇偏好 和青春期前的老鼠 简单地说,一种动物(示范者)是 在30分钟前不久灌胃给予一定剂量的乙醇 与实验对象(观察者)的行为互动。 在 几个实验表明,观察者随后会增加他们的 酒精摄入量超过对照水平的75 - 150%。 我们的工作假设 是观察者通过呼吸检测到的乙醇信号 在大鼠内源性碳基成分存在下的演示器 呼吸(二硫化碳),二硫化碳促进释放 内源性阿片类药物,功能上作为 调节对乙醇的偏好。 为了验证这个假设,我们将 研究内源性阿片类物质在促进乙醇增加中的作用, 主要通过操纵mu和kappa值来调节摄入模式 阿片受体 这项工作的最终结果将是增加 了解社会性行为背后的神经化学和行为因素 获得乙醇优惠。

项目成果

期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cholinergic modulation of trace conditioning trained in serial compound: A developmental analysis.
在系列化合物中训练的微量调节的胆碱能调节:发育分析。
  • DOI:
    10.1016/j.nlm.2006.05.001
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Hunt,PamelaS;Barnet,RobertC;Shea,MeghanE;Baker,EricM
  • 通讯作者:
    Baker,EricM
Intermittent ethanol exposure in adolescent rats: dose-dependent impairments in trace conditioning.
青春期大鼠间歇性乙醇暴露:微量调节的剂量依赖性损伤。
Postnatal ethanol exposure disrupts signal detection in adult rats.
出生后接触乙醇会扰乱成年大鼠的信号检测。
  • DOI:
    10.1016/j.ntt.2005.07.002
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Woolfrey,KevinM;Hunt,PamelaS;Burk,JoshuaA
  • 通讯作者:
    Burk,JoshuaA
Neonatal treatment with a competitive NMDA antagonist results in response-specific disruption of conditioned fear in preweanling rats.
使用竞争性 NMDA 拮抗剂进行新生儿治疗会导致断奶前大鼠条件性恐惧的反应特异性破坏。
  • DOI:
    10.1007/s00213-005-0291-1
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Hunt,PamelaS
  • 通讯作者:
    Hunt,PamelaS
Early postnatal ethanol administration does not affect prepulse inhibition in rats.
出生后早期施用乙醇不影响大鼠的前脉冲抑制。
  • DOI:
    10.1016/j.physbeh.2005.03.003
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Woolfrey,KevinM;Musisca,NicholasJ;Hunt,PamelaS;Burk,JoshuaA
  • 通讯作者:
    Burk,JoshuaA
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PAMELA S HUNT其他文献

PAMELA S HUNT的其他文献

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{{ truncateString('PAMELA S HUNT', 18)}}的其他基金

Mechanisms of Trace Fear Conditioning in the Developing Rat
发育中大鼠的微量恐惧调节机制
  • 批准号:
    8291269
  • 财政年份:
    2011
  • 资助金额:
    $ 9.27万
  • 项目类别:
Mechanisms of Trace Fear Conditioning in the Developing Rat
发育中大鼠的微量恐惧调节机制
  • 批准号:
    8206412
  • 财政年份:
    2011
  • 资助金额:
    $ 9.27万
  • 项目类别:
Neonatal Ethanol-Induced Memory Impairments in Rats
新生大鼠乙醇引起的记忆障碍
  • 批准号:
    6850358
  • 财政年份:
    2005
  • 资助金额:
    $ 9.27万
  • 项目类别:
Neonatal Ethanol-Induced Memory Impairments in Rats
新生大鼠乙醇引起的记忆障碍
  • 批准号:
    7227123
  • 财政年份:
    2005
  • 资助金额:
    $ 9.27万
  • 项目类别:
Neonatal Ethanol-Induced Memory Impairments in Rats
新生大鼠乙醇引起的记忆障碍
  • 批准号:
    7414385
  • 财政年份:
    2005
  • 资助金额:
    $ 9.27万
  • 项目类别:
Neonatal Ethanol-Induced Memory Impairments in Rats
新生大鼠乙醇引起的记忆障碍
  • 批准号:
    7058865
  • 财政年份:
    2005
  • 资助金额:
    $ 9.27万
  • 项目类别:
Neonatal Ethanol-Induced Memory Impairments in Rats
新生大鼠乙醇引起的记忆障碍
  • 批准号:
    7614358
  • 财政年份:
    2005
  • 资助金额:
    $ 9.27万
  • 项目类别:
SOCIAL LEARNING AND ALCOHOL INTAKE IN ADOLESCENT RATS
青春期大鼠的社交学习和酒精摄入量
  • 批准号:
    6371595
  • 财政年份:
    2000
  • 资助金额:
    $ 9.27万
  • 项目类别:
SOCIAL LEARNING AND ALCOHOL INTAKE IN ADOLESCENT RATS
青春期大鼠的社交学习和酒精摄入量
  • 批准号:
    6051277
  • 财政年份:
    2000
  • 资助金额:
    $ 9.27万
  • 项目类别:
CHRONIC POSTNATAL ALCOHOL AND ATTENTION IN THE RAT
大鼠慢性产后酒精和注意力
  • 批准号:
    6040591
  • 财政年份:
    2000
  • 资助金额:
    $ 9.27万
  • 项目类别:
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