Molecular Basis of Skeletal Growth in Renal Failure

描述(由申请人提供)： 生长衰竭在慢性肾脏病(CKD)儿童移植前和移植后都非常普遍，是发病率和死亡率的重要原因。直线生长受损的原因可能包括蛋白质能量营养不良、慢性代谢性酸中毒和贫血、反复感染、内分泌疾病和类固醇治疗。尽管进行了积极的支持性治疗，但这种情况仍然存在，其对神经认知发育的影响尚不清楚。确定控制正常骨骼生长和发育的分子事件可能：1)使我们更好地了解肾性骨营养不良和慢性肾脏病生长障碍儿童的病理生理学机制；2)指导针对这些疾病的新的和改进的治疗方法，从而实现充分的生长潜力和全面发展。这些目标是国际儿科肾病协会(IPNA)主办的第七届慢性肾功能衰竭儿童生长发育研讨会的基础，该研讨会将于2004年4月1日至4日在德国海德堡举行。这次会议建立在前六届国际科学会议的成功基础上，并将继续为基础和临床研究人员之间的互动提供机会，研究继发于CKD的骨骼生长和错位。将介绍有关正常和异常骨骼生长的分子机制的最新科学信息，目的是为CKD生长障碍的病理生理学研究和治疗开辟新的方向。青年研究人员和受训人员参与肾脏病学和内分泌学，并特别考虑在科学界任职人数不足的个人，这将是本次专题讨论会的主要目标，并将通过旅费赠款实现。科学组织委员会选择的两个海报会议将为这些参与者提供一个论坛，在发表在《国际儿科肾脏病杂志》增刊之前介绍他们的工作以供批判性审查。会议通知将通过邮件、期刊、网站和电子邮件送达北美和南美、欧洲、亚洲和其他国际儿科肾病学会。

DESCRIPTION (provided by applicant): Growth failure is highly prevalent in children with chronic kidney disease (CKD) both pre-and post-transplantation, and is a significant cause of morbidity and mortality. The causes of impaired linear growth may include protein energy malnutrition, chronic metabolic acidosis and anemia, recurrent infections, endocrinopathies, and steroid therapy. Despite aggressive supportive therapies, the condition persists and its impact on neurocognitive development is unknown. Identification of the molecular events controlling normal skeletal growth and development may: l ) allow better understanding of the pathophysiology of renal osteodystrophy and growth failure children with CKD; and, 2) direct new and improved therapies for these disorders resulting in the achievement of full growth potential and overall development. These goals serve as the basis for the International Pediatric Nephrology Association (IPNA)-sponsored Seventh Symposium on Growth and Development in Children with Chronic Renal Failure: The Molecular Basis of Skeletal Growth, to be held in Heidelberg, Germany, April 1-4, 2004. This conference builds on the success of the prior six such international scientific meetings and will continue to provide the opportunity for interaction between basic and clinical investigators studying skeletal growth and derangement secondary to CKD. Up to date scientific information regarding the molecular mechanisms for both normal and abnormal skeletal growth will be presented with the goal of developing new directions for research and treatment of the pathophysiology of growth failure in CKD. Participation of young investigators and trainees in nephrology and endocrinology with special consideration given to individuals who are underrepresented in science, will be a primary goal of this symposium and will be achieved by travel grants. Two poster sessions selected by the Scientific Organizing Committee will provide a forum for these participants to present their work for critical review prior to publication in a supplemental issue of the International Journal of Pediatric Nephrology. Meeting announcements via mail, journals, websites, and emails will reach the North and South American, European, Asian, and other International Societies of Pediatric Nephrology.