Molecular Basis of Skeletal Growth in Renal Failure

肾衰竭时骨骼生长的分子基础

• 批准号: 6718685
• 负责人: Frederick Kaskel
• 金额: $ 1.5万
• 依托单位: MONTEFIORE MEDICAL CENTER (BRONX, NY)
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2004-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6718685
• 关键词: bone development; meeting /conference /symposium; renal failure; skeletal system; travel

DESCRIPTION (provided by applicant): Growth failure is highly prevalent in children with chronic kidney disease (CKD) both pre-and post-transplantation, and is a significant cause of morbidity and mortality. The causes of impaired linear growth may include protein energy malnutrition, chronic metabolic acidosis and anemia, recurrent infections, endocrinopathies, and steroid therapy. Despite aggressive supportive therapies, the condition persists and its impact on neurocognitive development is unknown. Identification of the molecular events controlling normal skeletal growth and development may: l ) allow better understanding of the pathophysiology of renal osteodystrophy and growth failure children with CKD; and, 2) direct new and improved therapies for these disorders resulting in the achievement of full growth potential and overall development. These goals serve as the basis for the International Pediatric Nephrology Association (IPNA)-sponsored Seventh Symposium on Growth and Development in Children with Chronic Renal Failure: The Molecular Basis of Skeletal Growth, to be held in Heidelberg, Germany, April 1-4, 2004. This conference builds on the success of the prior six such international scientific meetings and will continue to provide the opportunity for interaction between basic and clinical investigators studying skeletal growth and derangement secondary to CKD. Up to date scientific information regarding the molecular mechanisms for both normal and abnormal skeletal growth will be presented with the goal of developing new directions for research and treatment of the pathophysiology of growth failure in CKD. Participation of young investigators and trainees in nephrology and endocrinology with special consideration given to individuals who are underrepresented in science, will be a primary goal of this symposium and will be achieved by travel grants. Two poster sessions selected by the Scientific Organizing Committee will provide a forum for these participants to present their work for critical review prior to publication in a supplemental issue of the International Journal of Pediatric Nephrology. Meeting announcements via mail, journals, websites, and emails will reach the North and South American, European, Asian, and other International Societies of Pediatric Nephrology.

描述（由申请人提供）： 生长衰竭在移植前后的慢性肾脏病（CKD）儿童中非常普遍，并且是发病率和死亡率的重要原因。线性生长受损的原因可能包括蛋白质能量营养不良、慢性代谢性酸中毒和贫血、复发性感染、内分泌病和类固醇治疗。尽管有积极的支持治疗，但病情仍然存在，其对神经认知发育的影响尚不清楚。控制正常骨骼生长和发育的分子事件的鉴定可以：1）允许更好地理解患有CKD的肾性骨营养不良和生长衰竭儿童的病理生理学;和，2）指导用于这些疾病的新的和改进的疗法，从而实现完全生长潜力和整体发育。这些目标是国际儿科肾病协会（IPNA）主办的第七届慢性肾衰竭儿童生长发育研讨会的基础：Skeletal生长的分子基础，将于2004年4月1-4日在德国海德堡举行。本次会议建立在前六次此类国际科学会议的成功基础上，并将继续为研究继发于CKD的骨骼生长和紊乱的基础和临床研究者之间的互动提供机会。将提供有关正常和异常骨骼生长分子机制的最新科学信息，目标是为研究和治疗慢性肾脏病生长障碍的病理生理学开辟新方向。青年研究人员和实习生参与肾脏病学和内分泌学，特别考虑到科学界代表性不足的个人，将是这次研讨会的主要目标，并将通过旅费赠款实现。科学组织委员会选择的两个海报会议将为这些参与者提供一个论坛，在国际儿科肾病杂志增刊发表之前，介绍他们的工作以进行严格审查。会议公告将通过邮件、期刊、网站和电子邮件发送到北美、南美、欧洲、亚洲和其他国际儿科肾病学会。