International Pediatric Nephrology Association (IPNA) Eighth Symposium on Growth

国际儿科肾病协会（IPNA）第八届慢性肾病儿童生长和营养研讨会将讨论儿科肾病学家和内分泌学家在照顾有显著合共病和死亡风险的婴儿、儿童和青少年生长障碍方面面临的主要挑战。本次研讨会将在前几届会议成功的基础上提供：1)对突出的热点话题进行深入的讨论和更新；2)正在进行的和创新的研究路线的信息；3)临床和基础研究人员之间互动的适当框架；4)鼓励新研究小组和年轻研究人员的加入。生长迟缓是儿童时期CKD的常见结果，导致患者无法达到与其遗传潜力一致的最终成年身高。尽管我们对生长异常的细胞和分子病因的理解取得了重大进展，以及针对预防或纠正生长缺陷的明确治疗方法，但在北美儿童肾脏试验和合作研究数据库中，37%的CKD儿童患有法定生长障碍。此外，来自美国肾脏数据系统数据库的数据表明，重度至中度生长衰竭患者的住院率和死亡风险增加。生长障碍在CKD儿童发病心血管危险因素的高发病率和患病率中的作用仍有待研究。考虑到这些问题，以及目前niddk支持的儿童慢性肾脏疾病队列研究的结果，在IPNA的指导下，一个国际科学组织委员会召集了一组杰出的研究人员，他们在健康和疾病的生长及其调节方面具有专业知识，以便在西班牙Olviedo召开为期三天的互动科学会议。旨在促进该领域的新研究，促进新的研究人员和学员的发展。竞争性差旅补助将为他们提供出席和参与会议的机会，并参加经同行评审的研究海报会议，以获得高级研究人员的重要反馈。网站将发布会议信息。

DESCRIPTION (provided by applicant): The International Pediatric Nephrology Association's (IPNA) Eighth Symposium on Growth and Nutrition in Children with Chronic Renal Disease will address the major challenges facing pediatric nephrologists and endocrinologists in the care of infants, children and adolescents with disorders of growth who are at risk for significant co-morbidities and mortality. The symposium will build upon the success of the prior conferences to provide: 1) in depth-discussion and updates on outstanding hot topics, 2) information on ongoing and innovative lines of research, 3) the proper framework for interaction between clinical and basic investigators, and 4) a stimulus for the incorporation of new groups of research and young investigators. Growth retardation is a common result of CKD in childhood and results in failure of the patient to achieve the final adult height consistent with their genetic potential. Despite major advances in our understanding of the cellular and molecular etiologies for the growth abnormalities, as well as, well-defined therapies aimed at preventing or correcting the growth defects, 37% of children with CKD in the North American Pediatric Renal Trials and Collaborative Studies database had statutory growth impairment. Additionally, data from the United States Renal Data System database has demonstrated that patients with severe-to-moderate growth failure had increased hospitalizations rates and increased risk of death. The role of growth impairment in the higher incidence and prevalence of pediatric-onset cardiovascular risk factors in CKD remains to be characterized. With these issues in mind, and the results of the current NIDDK-support Chronic Kidney Disease in Children Cohort Study, an international scientific organizing committee under the guidance of the IPNA, has assembled a distinguished group of investigators with expertise in growth and its regulation in health and disease, in order to convene a three day interactive scientific meeting in Olviedo, Spain, aimed at stimulating new research in the field and facilitating the development of new investigators and trainees. Competitive travel grants will provide the opportunity for their attendance and participation in the meeting with peer-reviewed poster sessions of their research for critical feedback from senior investigators. A website will disseminate meeting information.