International Pediatric Nephrology Association (IPNA) Eighth Symposium on Growth

描述（由申请人提供）：国际儿科肾脏病协会（IPNA）第八届慢性肾脏病儿童生长和营养研讨会将讨论儿科肾脏病学家和内分泌学家在护理患有生长障碍的婴儿、儿童和青少年时面临的主要挑战，这些婴儿、儿童和青少年有显著的合并症和死亡风险。研讨会将建立在以前会议的成功，提供：1）深入讨论和更新突出的热点话题，2）正在进行的和创新的研究线的信息，3）临床和基础研究人员之间的互动的适当框架，和4）对研究和年轻研究人员的新群体的合并的刺激。生长迟缓是儿童期CKD的常见结果，导致患者无法达到与其遗传潜力一致的最终成人身高。尽管我们对生长异常的细胞和分子病因学的理解取得了重大进展，以及旨在预防或纠正生长缺陷的明确治疗，但在北美儿科肾脏试验和协作研究数据库中，37%的CKD儿童患有法定生长障碍。此外，来自美国肾脏数据系统数据库的数据表明，重度至中度生长衰竭患者的住院率增加，死亡风险增加。生长障碍在CKD儿童期心血管危险因素发生率和患病率较高中的作用仍有待确定。考虑到这些问题，以及目前NIDDK支持的儿童慢性肾脏病队列研究的结果，在IPNA的指导下，一个国际科学组织委员会召集了一个杰出的研究人员小组，他们具有生长及其在健康和疾病中的调节方面的专业知识，以便在西班牙奥尔维耶多召开为期三天的互动科学会议，旨在激励该领域的新研究，促进新调查员和受训人员的发展。竞争性旅费补助金将为他们提供机会，使他们能够出席和参加会议，参加同行审查的研究海报会议，以征求高级调查员的重要反馈。一个网站将传播会议信息。

DESCRIPTION (provided by applicant): The International Pediatric Nephrology Association's (IPNA) Eighth Symposium on Growth and Nutrition in Children with Chronic Renal Disease will address the major challenges facing pediatric nephrologists and endocrinologists in the care of infants, children and adolescents with disorders of growth who are at risk for significant co-morbidities and mortality. The symposium will build upon the success of the prior conferences to provide: 1) in depth-discussion and updates on outstanding hot topics, 2) information on ongoing and innovative lines of research, 3) the proper framework for interaction between clinical and basic investigators, and 4) a stimulus for the incorporation of new groups of research and young investigators. Growth retardation is a common result of CKD in childhood and results in failure of the patient to achieve the final adult height consistent with their genetic potential. Despite major advances in our understanding of the cellular and molecular etiologies for the growth abnormalities, as well as, well-defined therapies aimed at preventing or correcting the growth defects, 37% of children with CKD in the North American Pediatric Renal Trials and Collaborative Studies database had statutory growth impairment. Additionally, data from the United States Renal Data System database has demonstrated that patients with severe-to-moderate growth failure had increased hospitalizations rates and increased risk of death. The role of growth impairment in the higher incidence and prevalence of pediatric-onset cardiovascular risk factors in CKD remains to be characterized. With these issues in mind, and the results of the current NIDDK-support Chronic Kidney Disease in Children Cohort Study, an international scientific organizing committee under the guidance of the IPNA, has assembled a distinguished group of investigators with expertise in growth and its regulation in health and disease, in order to convene a three day interactive scientific meeting in Olviedo, Spain, aimed at stimulating new research in the field and facilitating the development of new investigators and trainees. Competitive travel grants will provide the opportunity for their attendance and participation in the meeting with peer-reviewed poster sessions of their research for critical feedback from senior investigators. A website will disseminate meeting information.