CKID

CKID

• 批准号: 7608076
• 负责人: Frederick Kaskel
• 金额: $ 0.66万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608076
• 关键词: Age; Behavior assessment; Biological; Blood Pressure; Child; Chronic Kidney Failure; Cognitive; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Creatinine; Development; Disease Progression; Enrollment; Failure; Functional disorder; Funding; Genetic; Glomerular Filtration Rate; Goals; Grant; Growth; Institution; Iohexol; Kidney; Measurement; Measures; Neurocognitive; Parathyroid hormone measurement; Prevalence; Questionnaires; Range; Research; Research Personnel; Resources; Risk Factors; Sampling; Serum; Source; Staging; United States National Institutes of Health; Visit; base; cardiovascular disorder risk; follow-up; post gamma-globulins

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is an observational cohort study over a 5 year period from October 2003 through July 2008 that has a recruitment goal of 540 children with mild to moderate kidney dysfunction with an estimated glomerular filtration rate from 30 to 90 ml/min/1.73m2 ranging in age from 1 through 16 years. 402/540 (75%) enrollment goal as of 1.16/07 has been meet with a retention of 95.3% at 6 month follow up visit. The goals of the study are to define risk factors for chronic kidney disease (CKD) progression and to define the effects of CKD progression on: neurocognitive developmental function, prevalence of cardiovascular disease risk factors, and growth failure. The scientific domains and key measures involve questionnaires and forms, iohexol-based GFR, cystatin C and serum creatinine, echo and ambulatory blood pressure measurement, cognitive development and behavioral assessment, tanner staging and parathyroid hormone measurement, and stored biological samples and genetic studies.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一项从2003年10月至2008年7月为期5年的观察性队列研究，招募目标为540例轻度至中度肾功能不全儿童，估计肾小球滤过率为30 - 90 ml/min/1.73 m2，年龄范围为1 - 16岁。 截至2007年1月16日，402/540（75%）例患者达到入组目标，6个月随访访视时保留率为95.3%。 该研究的目的是确定慢性肾脏病（CKD）进展的风险因素，并确定CKD进展对神经认知发育功能、心血管疾病风险因素的患病率和生长衰竭的影响。 科学领域和关键措施包括问卷和表格，基于碘海醇的GFR，胱抑素C和血清肌酐，超声心动图和动态血压测量，认知发展和行为评估，坦纳分期和甲状旁腺激素测量，以及储存的生物样本和遗传研究。