ASM Conference on Biofilms 2003

2003 年 ASM 生物膜会议

• 批准号: 6755809
• 负责人: MATTHEW R. PARSEK
• 金额: $ 2.5万
• 依托单位: AMERICAN SOCIETY FOR MICROBIOLOGY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-25 至 2004-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6755809
• 关键词: biofilm; meeting /conference /symposium; microbiology; travel

DESCRIPTION (provided by applicant): The ubiquity of surface-associated microbial life, or biofilms, has long been appreciated by researchers in many fields. Biofilms have also long been known to play benign and harmful roles in many environmental, industrial, and clinical processes. Only recently though, have researchers begun to demonstrate that biofilm formation in many cases proceeds through a developmental cycle, characterized by specific expression of certain genes and proteins at different points in the cycle. Much of the initial work has been conducted in the opportunist, Pseudomonas aeruginosa, although similar studies have been conducted in a variety of organisms. This work has lead to an appreciation that only studying free-swimming bacteria can lead to a biased view of microbial life. Interest in clinically related research on biofilms has been particularly great. This is not surprising- the difficulty of eradicating biofilm bacteria with antibiotic treatment is a prime concern of medicine. Depending upon the organism, type of antimicrobial and experimental system, biofilm bacteria can be up to a thousand times more resistant to antimicrobial stress than free-swimming bacteria of the same species. Understanding the nature of the increased antimicrobial resistance is a central goal of much clinical and basic research on medically relevant biofilms today. Which infections are caused by biofilms, and how is this determination made? Unfortunately, this is a difficult question for a number of reasons. In many human infections the bacteria are difficult to access, and biofilm and planktonic growth may co-exist. Furthermore there is no definitive physiological marker of the biofilm state for a bacterium. Biofilms are an organized mode of growth; consequently this phenotype is rapidly lost when bacteria are cultured ex vivo in liquid culture. With the recent explosion of biofilm-related research in microbial biofilms, ASM is sponsoring a meeting called Biofilms 2003 to be held in Victoria, British Columbia. This meeting will allow researchers to gather and discuss their work. We request funds for this meeting and hope that NIH will support ASM in providing financial assistance.

描述（由申请人提供）：表面相关微生物生命或生物膜的普遍存在长期以来一直受到许多领域研究人员的重视。长期以来，人们也知道生物膜在许多环境、工业和临床过程中起着良性和有害的作用。然而，直到最近，研究人员才开始证明，在许多情况下，生物膜的形成是通过一个发育周期进行的，其特征是某些基因和蛋白质在周期的不同点特异性表达。许多初步的工作已经进行了机会主义，铜绿假单胞菌，虽然类似的研究已经进行了各种生物。这项工作使人们认识到，只有研究自由游动的细菌才能导致对微生物生命的偏见。 对生物膜的临床相关研究的兴趣特别大。这并不奇怪-用抗生素治疗根除生物膜细菌的困难是医学的主要关注点。根据生物体、抗微生物剂类型和实验系统，生物膜细菌对抗微生物剂应激的抗性可以比相同物种的自由游动细菌高出上千倍。了解增加的抗菌素耐药性的性质是当今医学相关生物膜的许多临床和基础研究的中心目标。哪些感染是由生物膜引起的，如何确定？不幸的是，这是一个困难的问题，原因有很多。在许多人类感染中，细菌很难接近，生物膜和共生生长可能共存。此外，对于细菌，没有生物膜状态的确定性生理标志物。生物膜是一种有组织的生长模式;因此，当细菌在液体培养物中离体培养时，这种表型迅速丧失。 随着最近与微生物生物膜有关的研究的激增，ASM正在赞助一个名为“生物膜2003”的会议，该会议将在不列颠哥伦比亚省的维多利亚举行。这次会议将使研究人员聚集在一起讨论他们的工作。我们请求为这次会议提供资金，并希望NIH支持ASM提供财政援助。