FASEB Research Conf: Glucose Transporter Biology

描述（由申请人提供）： 这是一份申请，要求对美国实验生物学学会联合会（FASEB）主办的题为“葡萄糖转运生物学”的夏季研究会议提供部分支持。这次会议定于2003年8月9日至8月14日在科罗拉多的斯诺马斯村举行。这将是第六届一年两次的国际会议，专门致力于葡萄糖转运和代谢的细胞，分子和生理调节。本次会议的目的是关注新的，前沿的方法和发现，这些方法和发现直接影响我们对1）维持正常葡萄糖稳态所必需的复杂调节过程和2）导致该过程失调的病理条件，从而导致胰岛素抵抗和糖尿病。此外，本次会议将提供一个场所，鼓励和促进新的年轻研究人员在这一关键领域的疾病研究。总的来说，本次会议将限于150名来自具有临床和/或基础科学背景的个人的参与者，根据他们的专业知识和兴趣进行选择。将有8个主要的科学会议，包括4-5个特邀演讲，每个演讲约30分钟（20分钟+ 10分钟讨论），然后是15-30分钟的时间，其中将介绍选定的摘要和/或最新数据。每次会议结束时，还将有20分钟的时间进行全面的一般性讨论。在整个会议期间还将张贴海报，并将在两个下午的会议上组织具体的海报展示。口头介绍选定的海报摘要和海报会议本身将为初级参与者提供机会，与该领域的专家直接互动并讨论他们的数据。将讨论的八个具体主题包括：1）葡萄糖转运蛋白基因家族，2）GLUT表达的调节，3）葡萄糖转运蛋白生理学/病理生理学，4）葡萄糖利用和胰岛素敏感性生理学，5）运输囊泡运输，6）GLUT 4运输，7）GLUT 4信号传导，以及8）脂筏和小窝。在每一个这些会议的协议，争议和不确定性的领域将被定义和讨论。重要的是，选择这些领域是为了为对葡萄糖转运蛋白生物学/生物化学细胞生物学感兴趣的基础和临床科学家提供一个独特的机会，使他们能够相互交流，并与密切相关但不同研究领域的其他科学家交流。与以往一样，本次会议的互动环境将促进与会者之间的合作研究，并将确定我们对葡萄糖转运蛋白调节和负责维持葡萄糖稳态的机制的理解的未来关键目标。

DESCRIPTION (provided by applicant): This is an application requesting partial support for a summer research conference entitled "GLUCOSE TRANSPORTER BIOLOGY" sponsored by the Federation of American Societies for Experimental Biology (FASEB). This conference has been scheduled to take place from August 9 to August 14, 2003 in Snowmass Village, Colorado. This will be the sixth bi-annual international meeting specifically devoted to the cellular, molecular and physiological regulation of glucose transport and metabolism. The aim of this conference is to focus on novel, cutting-edge approaches and findings that have a direct impact on our understanding of 1) the complex regulatory processes that are necessary to maintain normal glucose homeostasis and 2) the pathological conditions that result in dysregulation of this process resulting in insulin resistance and diabetes. In addition, this conference will provide a venue to encourage and promote new young investigators in this critical area of disease research. In total, this conference will be limited to 150 participants from individuals with clinical and/or basic science backgrounds, selected on the basis of their expertise and interests. There will be eight major scientific sessions consisting of 4-5 invited talks, approximately 30 min each (20 min + 10 min discussion) followed by a 15-30 min period where selected abstracts and/or late breaking data will be presented. At the end of each session, there will also be a 20 min period for an overall general discussion. Posters will also be displayed throughout the duration of the meeting and specific poster presentations will be organized in two afternoon sessions. The oral presentation of selected poster abstracts and the poster sessions themselves will provide opportunities for junior participants to directly interact with and discuss their data with experts in the field. The eight specific topics that will be discussed include: 1) Glucose transporter gene family, 2) Regulation of GLUT expression, 3) Glucose transporter physiology/pathophysiology, 4) Physiology of glucose utilization and insulin-sensitivity, 5) Transport vesicle trafficking, 6) GLUT4 trafficking, 7) Signaling to GLUTs, and 8) Lipid rafts and caveolae. The areas of agreement, controversy, and uncertainty within each of these sessions will be defined and discussed. Importantly, these areas have been selected to provide a unique opportunity for basic and clinical scientists interested in glucose transporter biology/biochemistry cell biology to interact with each other and with other scientists in closely related but distinct research fields. As has previously been the case, the interactive environment at this conference will stimulate collaborative research efforts among the conferees and will identify the future critical goals for our understanding of glucose transporter regulation and the mechanisms responsible for the maintenance of glucose homeostasis.