Gordon Research Conference On Cell Contact And Adhesion

描述（由申请人提供）：资金要求支持戈登会议“细胞接触和粘附”，将举行第十六次（第30年），2002年6月8日至13日在普罗克特学院，安多弗，NH。 这次会议的持久性证明了它作为细胞-细胞相互作用领域关键会议的重要性。 它是跨学科的，包括分子，结构，遗传和细胞方法来解剖细胞-细胞接触的结构，确定它们的细胞，组织学和生物体作用及其在人类疾病中的参与，包括癌症和发育缺陷。 今年会议的重点将是粘附和封闭型细胞-细胞接触在形态发生中的作用。 会议将吸引分子，细胞，癌症和发育生物学家。 会议涵盖了令人兴奋的领域和最近的进展，包括：细胞接触的作用：细胞极性，不对称细胞分裂和平面极性。 两次会议将涵盖干细胞存活和细胞命运决定中细胞接触的作用。 这个主题已经产生了很多兴奋，并将在血管和心脏系统，表皮和乳腺中进行探索。 三个会议将涵盖细胞接触蛋白及其相关的衔接蛋白在信号转导过程中的作用，管理增殖控制，细胞骨架重组，癌症和转移。 发言者名单包括在这一领域活跃的知名科学家，以及最近贡献了深刻数据的年轻调查人员和初级学员。 选择这些主席是因为他们有能力就广泛的议题展开讨论。 按照本次会议的传统，上届会议保留了四个时段，以列入最新的发展动态，并在每届会议结束时分配了一个简短的谈话时段，以突出有前途的年轻调查人员的工作。 这次会议将汇集在脊椎动物和无脊椎动物系统谁不满足在其他论坛工作的科学家。 细胞与细胞接触的组成部分是肿瘤抑制因子和癌基因，因此这次会议将与NCI的使命高度相关。 细胞-细胞接触蛋白提供了在胚胎发生过程中将细胞结合成功能组织的物理力量，正如本次会议强调的遗传方法所示，这些成分的缺陷导致出生缺陷，这与NICHD的使命高度相关。 这次会议也与NIDDK、NIAMS、NHLBI和NIGMS的使命有关，并将报告也由NIDDK、NIAMS、NHLBI和NIGMS资助的研究。

DESCRIPTION (provided by applicant): Funds are requested to support the Gordon Conference "Cell Contact and Adhesion" that will be held for the sixteenth time (30th year), June 8-13, 2002 at Proctor Academy, Andover, NH. The endurance of this conference testifies to its importance as a key meeting for the field of cell-cell interactions. It is interdisciplinary, encompassing molecular, structural, genetic and cellular approaches to dissecting the architecture of cell-cell contacts, determining their cellular, histological, and organismal roles and their involvement in human disease including cancer and developmental defects. The focus of this year's meeting will be the role of adhesive and occludens type cell-cell contacts in morphogenesis. The conference will interest molecular, cell, cancer and developmental biologists. The sessions cover areas of exciting and recent progress including: The role of cell contacts in: cell polarity, asymmetric cell division and planar polarity. Two sessions will cover the role of cell contacts in stem cell survival and cell fate determination. This theme has generated much excitement and will be explored in the vascular and cardiac system, epidermis and mammary gland. Three sessions will cover the role of cell contact proteins and their associated adaptor proteins in signal transduction processes governing proliferative control, cytoskeletal reorganization, cancer and metastasis. The roster of speakers includes established and renowned scientists who are active leaders in this field as well as young investigators and junior trainees who have recently contributed incisive data. The chairs have been chosen for their ability to generate discussion on a wide range of topics. As is traditional for this meeting, four slots have been reserved in the last session for the inclusion of late breaking developments and a short talk slot has been allocated at the end of each session to highlight the work of promising young investigators. This conference will bring together scientists working in vertebrate and invertebrate systems who do not meet in other forums. The components of cell-cell contacts are tumor suppressors and oncogenes and thus this conference will be highly relevant for the mission of the NCI. Cell-cell contact proteins provide the physical force that unite cells into functional tissues during embryogenesis and, as the genetic approaches highlighted in this meeting show, defects in these components lead to birth defects that are highly relevant to the mission of NICHD. This conference is also relevant to the mission of, and will report research that is also funded by NIDDK, NIAMS, NHLBI and NIGMS.