Synthetic Extremophiles: Cellular bionics for extreme conditions

合成极端微生物：极端条件下的细胞仿生学

• 批准号: 2281778
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2281778
• 关键词: Synthetic; Extremophiles; Cellular; bionics; extreme

helping organisms to survive in their ecological niches. Such adaptations can be structural, behavioural or physiological. In the case of extremophiles this trait extends to enabling life to thrive in forbidding environments that were once not thought to be able to sustain life: from extremes of pressure all the way through to extremes of temperature. This studentship aims for the first time to generate biological-synthetic hybrid systems that are capable of surviving extremes of pressure (equivalent to being at the bottom of the Mariana Trench, the deepest ocean point in the world; >1000atm)-synthetic extremophiles. By fusing living and non-living systems we will generate ensembles that are able to modify their composition and make-up in response to external changes in hydrostatic pressure. This has the potential to transform our understanding of how molecular components come together to introduce emergent behaviour. In addition, it will lead to the manufacture of biological components that are ideally suited to a wide range of industrial, bio technical and consumer applications where performance under extreme conditions and the capability to respond to extreme operating conditions are fundamental prerequisites.

帮助有机体在其生态环境中生存。这种适应可以是结构性的，可以是行为的，也可以是生理的。就极端微生物而言，这一特征使生命能够在曾经被认为无法维持生命的恶劣环境中茁壮成长：从极端的压力一直到极端的温度。该项目的目标是首次开发能够在极端压力下(相当于在世界上最深的海洋点马里亚纳海沟的底部；1000atm)生存的生物-合成混合系统-人工合成极端微生物。通过融合生物和非生物系统，我们将产生能够根据外界静水压力变化改变其组成和组成的合奏。这有可能改变我们对分子成分如何聚集在一起引入紧急行为的理解。此外，它还将导致制造非常适合于各种工业、生物技术和消费应用的生物组件，在这些应用中，极端条件下的性能和对极端操作条件的反应能力是基本先决条件。