Gordon Conferecnce on Oxidative Stress and Disease

描述(由申请人提供) 要求提供资金以支持将在加利福尼亚州文图拉举行的戈登氧化应激与疾病研究会议。2003年3月。这将是这次戈登会议的第二次会议。首届大会于2001年3月举行，取得了巨大成功，与会者给予了极好的评价。会议的成功在很大程度上源于能够有效地整合各种主题和疾病状态，所有这些都具有氧化应激这一共同的潜在主题。在即将到来的会议上，这种融合科学多样性的传统将继续下去。在此建议举行九次科学会议。其中两节讨论了活性氧对衰老过程的影响，随后的一节专门讨论了线粒体在氧自由基应激中的作用。还包括一节关于抗氧化疗法的课程。其他会议专门讨论以这种或那种形式与氧化损伤相关的特定疾病状态。这些疾病包括神经退行性变、金属超负荷疾病、微生物致病和癌症。最后，会议将以一场关于预防氧化应激相关疾病的信号通路的会议结束。会议的总主题是“从化学到临床”，将介绍氧化损伤的多个方面，从基础活性氧化学到模型生物体研究，再到人类疾病病理学。这次会议将吸引化学家、生物学家和临床医生，他们都有一个共同的目标，就是了解氧化损伤对健康的影响。发言者是根据他们在科学上的卓越表现和对该领域的贡献挑选出来的。对年轻调查人员和妇女给予了特别考虑。请拨经费以支付受邀发言者和讨论负责人以及申请参加会议的10名初级调查员的旅费和会议费。

DESCRIPTION (provided by applicant) Funds are requested to support the Gordon Research Conference on Oxidative Stress and Disease to be held in Ventura, Ca. in March of 2003. This will represent the second meeting of this particular Gordon Conference. The inaugural conference was held in March of 2001 and was a big success, with outstanding reviews from the attendees. The success of the meeting largely stemmed from the ability to effectively integrate a diversity of topics and disease states, all with the common underlying theme of oxidative stress. In the upcoming meeting, this tradition of integrating scientific diversity will be continued. Nine scientific sessions are proposed herein. Two deal with the impact of reactive oxygen on the aging process, followed by a session devoted to the role of mitochondria in oxygen radical stress. A session on anti-oxidant therapeutics is also included. Other sessions are dedicated to specific disease states that have in one form or another, been associated with oxidative damage. These include neurodegeneration, diseases of metal overload, microbial pathogenic and cancer. Finally, the meeting will conclude with a session on signaling pathways for guarding against oxidative stress related disorders. The overall theme of the meeting is "from chemistry to the clinics" and multiple aspects of oxidative damage will be presented, from basic reactive oxygen chemistry to model organism studies to human disease pathology. The meeting will attract chemists, biologists and clinicians alike, all with the common goal of understanding the impact of oxidative damage on health. The speakers were selected on the basis of their scientific excellence and contributions to the field. Special consideration was given to young investigators and women. Funds are requested to support the travel and meeting expenses of the invited speakers and discussion leaders as well as 10 junior investigators that apply to the meeting.