CORE--MOLECULAR TOXICOLOGY

描述（由申请人提供）：分子毒理学核心的总体目标是汇集一组选定的生物学家，他们的研究兴趣包括研究各种物质（包括金属、ROS、有机异生物质和DNA损伤剂）造成的损伤的基本毒性机制。一个目标是集中他们不同的专业知识和兴趣的方面，以促进跨学科的互动和合作的研究，解决有关人类健康的重要问题，在城市环境。 另一个目标是让核心研究者作为所有中心研究核心的研究者的基础实验室科学和分子技术资源。分子毒理学核心的目标是通过以下活动促进：首先，核心在学年期间举行每月的研究会议，其中几个教师讨论他们实验室的当前研究活动。每位研究者都有1/2小时的时间来介绍最新进展（许多未发表的工作），并且还有充足的时间与其他研究者进行公开讨论。会议不仅对主要研究人员开放，还对研究核心3实验室的所有成员开放，包括工作人员和学生。这些会议非常成功，除了研究会谈外，还讨论了核心开发和研究内部/研究之间合作的想法/计划，试点项目，共享资源的需求等。此外，在这些会议期间还提供了关于核心设施增加的最新情况。例如，Guilarte博士最近概述了可用的成像设施。他的演讲引起了包括Biswal博士在内的研究核心3的几位研究人员的兴趣，这些信息对促进Biswal博士的研究计划的发展非常有帮助。第二，所有核心成员沿着其他中心成员和环境健康科学培训计划的成员及其学生参加年度科学研讨会。在这种情况下，一个受邀的演讲者（S）提出了一个研讨会，然后由研究生和培训计划和中心教师的海报演示。 第三，核心成员和中心成员之间的互动也通过共享使用核心设施来促进，在那里交流技术和实验方法的使用知识。第四，核心本身，并与其他中心的研究核心，赞助中心范围内的研讨会提出的霍普金斯教师和外部发言人。第五，所有中心成员都收到年度进展报告的副本，这有助于中心调查人员了解 每个研究和设施核心和整个中心的活动。

Description (provided by applicant): The overall objective of the Molecular Toxicology Core is to bring together a group of selected biologists whose research interests include studies on fundamental mechanisms of toxicity due to damage from a variety of agents including metals, ROS, organic xenobiotics and DNA damaging agents. A goal is to focus aspects of their diverse expertise and interests to foster interdisciplinary interactions and collaborations on research which addresses important problems relevant to human health in an urban environment. Another goal is to have Core Investigators serve as a resource of fundamental laboratory science and molecular technology to investigators in all Center Research Cores. The goals of the Molecular Toxicology Core are facilitated by the following activities: First, the Core holds monthly research meetings during the academic year where several faculty discuss the current research activities in their labs. Each investigator is provided with 1/2 hour to present recent advancements (much unpublished work) and is also provided ample time for open discussion with other investigators. The meetings are open to not only principal investigators, but also to all members of the Research Core 3 laboratories including staff and students. These meetings have been highly in successful in addition to research talks, ideas/plans for Core development and intra/inter-research Core collaborations, pilot projects, needs for shared resources, etc. are also discussed at these meetings. Moreover, recent updates on additions made to Core facilities are provided during these meetings. For example, Dr. Guilarte recently presented an overview of the imaging facilities that are available. His presentation sparked the interests of several investigators of Research Core 3, including Dr. Biswal and this information has been extremely helpful in fostering the development of Dr. Biswal's research program. Second, all Core Members along with other Center Members and members of the Environmental Health Sciences Training Program and their students participate in the annual Scientific Workshop. In this setting, an invited speaker(s) presents a seminar which is followed by poster presentations by graduate students and Training Program and Center faculty. Third, interaction among Core and Center Members is also facilitated through the shared use of Core facilities where knowledge of the use of techniques and experimental approaches is exchanged. Fourth, the Core itself, and in conjunction with other Center Research Cores, sponsors Center-wide seminars presented by Hopkins faculty and outside speakers. Fifth, all Center members receive copies of the annual progress reports and this serves to keep the Center investigators informed regarding the activities of each Research and Facility Core and the Center as a whole.