2009 Cell Biology of Metals Gordon Conference

描述（由申请人提供）：金属戈登会议的细胞生物学提供了一个论坛，生物无机化学家，金属生物学家和临床医生的金属相关疾病都满足和讨论在单细胞水平上理解金属稳态的最新进展。如何从细胞外环境中摄取金属离子并在细胞中适当地运输而不引起毒性的复杂性是一个日益重要的领域。越来越多的疾病被归因于细胞金属稳态的破坏。因此，2009年细胞生物学的金属戈登会议的目标是提出最新的突破，在细胞生物学的金属运输，贩运和解毒，以及这些发现如何与人类疾病。我们的具体目标是：1）组织一次会议，重点是金属的细胞生物学，并筹集资金，以支持在这一领域的初级研究人员出席; 2）促进科学思想的交流和不同的研究人员之间的合作，否则可能不会相互作用; 3）鼓励和促进年轻的研究人员，妇女和少数民族在会议。来自该领域领导者的演讲将跨越多个学科，从非常基础的生物无机到金属在疾病中的应用研究。示例会话包括：监测细胞中的金属，金属和氧化应激，以及微生物发病机制中的金属，神经变性和造血障碍。此外，在理解金属离子选择性和金属辅因子组装机制方面的新发现也将被提出。在所有会议上，重点将放在细胞生物学水平的发现。讲座将由特邀演讲者和选定的海报展示，并大力宣传该领域的初级调查员。主题将从微生物扩展到人类，跨越生物重要性的多个元素。 铜、锌、铁等金属离子是重要的营养元素。然而，当过量存在时，这些相同的元素是相当有毒的，并且已经归因于各种人类病症，包括神经、心血管和肾系统的疾病。在戈登会议上提出的科学有望为细胞管理这些潜在有毒和对生命至关重要的金属的机制提供新的重要线索。

DESCRIPTION (provided by applicant): The Cell Biology of Metals Gordon Conference provides a forum for which bioinorganic chemists, metallobiologists and clinicians for metal related disorders all meet and discuss the latest advances in understanding metal homeostasis at the single cell level. The complexity of how metal ions are taken up from the extracellular milieu and appropriately trafficked in a cell without causing toxicity is a field of growing importance. An increasing number of disorders are being attributed to disruptions in cellular metal homeostasis. As such, the goal of the 2009 Cell Biology of Metals Gordon conference is to present the latest breakthroughs in the cell biology of metal transport, trafficking and detoxification and how these findings relate to human disease. Our Specific Aims are: 1) To organize a conference that focuses on the cell biology of metals and to raise funds to support the attendance of junior investigators in this field; 2) To promote exchange of scientific ideas and collaborations among diverse investigators that may otherwise not interact; 3) To encourage and promote young investigators, women and minorities in the conference. Talks from leaders in the field will cross multiple disciplines, from the very basic bioinorganic to applied studies of metals in diseases. Sample sessions include: monitoring metals in cells, metals and oxidative stress, and metals in microbial pathogenesis, neurodegeneration and hematopoietic disorders. In addition, new discoveries in understanding mechanisms of metal ion selectivity and metal co-factor assembly will be presented. In all sessions, emphasis will be placed on discoveries made at cell biology level. Talks will be from invited speakers and from selected poster presentations, with much promotion of junior investigators in the field. Topics will expand from microbes to humans, cutting across multiple elements of biological importance. Metal ions such as copper, zinc and iron are important elements in nutrition. However, when present in excess these same elements are quite toxic and have been attributed to various human disorders including diseases of the nervous, cardio vascular and renal systems. The science to be presented at the Cell Biology of Metals Gordon conference promises to shed new important light into the mechanisms by which cells manage these metals that both potentially toxic and essential for life.