2009 Cell Biology of Metals Gordon Conference

2009年金属细胞生物学戈登会议

• 批准号: 7743607
• 负责人: Valeria C Culotta
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7743607
• 关键词: Biological; Cells; Cellular biology; Collaborations; Copper; Discipline; Disease; Drug Metabolic Detoxication; Elements; Fund Raising; Goals; Hematopoietic; Homeostasis; Human; Indium; Ions; Iron; Life; Light; Metals; Microbe; Minority; Monitor; Nerve Degeneration; Oxidative Stress; Pathogenesis; Research Personnel; Sampling; Science; System; Toxic effect; Woman; Zinc; extracellular; human disease; kidney vascular structure; meetings; microbial; nutrition; posters; symposium; trafficking

DESCRIPTION (provided by applicant): The Cell Biology of Metals Gordon Conference provides a forum for which bioinorganic chemists, metallobiologists and clinicians for metal related disorders all meet and discuss the latest advances in understanding metal homeostasis at the single cell level. The complexity of how metal ions are taken up from the extracellular milieu and appropriately trafficked in a cell without causing toxicity is a field of growing importance. An increasing number of disorders are being attributed to disruptions in cellular metal homeostasis. As such, the goal of the 2009 Cell Biology of Metals Gordon conference is to present the latest breakthroughs in the cell biology of metal transport, trafficking and detoxification and how these findings relate to human disease. Our Specific Aims are: 1) To organize a conference that focuses on the cell biology of metals and to raise funds to support the attendance of junior investigators in this field; 2) To promote exchange of scientific ideas and collaborations among diverse investigators that may otherwise not interact; 3) To encourage and promote young investigators, women and minorities in the conference. Talks from leaders in the field will cross multiple disciplines, from the very basic bioinorganic to applied studies of metals in diseases. Sample sessions include: monitoring metals in cells, metals and oxidative stress, and metals in microbial pathogenesis, neurodegeneration and hematopoietic disorders. In addition, new discoveries in understanding mechanisms of metal ion selectivity and metal co-factor assembly will be presented. In all sessions, emphasis will be placed on discoveries made at cell biology level. Talks will be from invited speakers and from selected poster presentations, with much promotion of junior investigators in the field. Topics will expand from microbes to humans, cutting across multiple elements of biological importance. Metal ions such as copper, zinc and iron are important elements in nutrition. However, when present in excess these same elements are quite toxic and have been attributed to various human disorders including diseases of the nervous, cardio vascular and renal systems. The science to be presented at the Cell Biology of Metals Gordon conference promises to shed new important light into the mechanisms by which cells manage these metals that both potentially toxic and essential for life.

金属细胞生物学戈登会议提供了一个论坛，让生物无机化学家、金属生物学家和金属相关疾病的临床医生齐聚一堂，讨论在单细胞水平上理解金属稳态的最新进展。金属离子如何从细胞外环境中被吸收并在细胞内适当运输而不引起毒性的复杂性是一个日益重要的领域。越来越多的疾病被归因于细胞金属稳态的破坏。因此，2009年戈登金属细胞生物学会议的目标是介绍金属运输、贩运和解毒的细胞生物学的最新突破，以及这些发现与人类疾病的关系。我们的具体目标是：1)组织一次以金属细胞生物学为重点的会议，并筹集资金支持该领域的初级研究人员参加；2)促进不同研究人员之间的科学思想交流和合作，否则可能不会相互影响；3)鼓励和提升青年研究人员、妇女和少数民族参加会议。来自该领域的领导者的演讲将跨越多个学科，从最基本的生物无机到金属在疾病中的应用研究。样本会议包括：监测细胞中的金属，金属和氧化应激，金属在微生物发病机制，神经变性和造血障碍。此外，还将介绍在理解金属离子选择性和金属辅助因子组装机制方面的新发现。在所有会议中，重点将放在细胞生物学水平上的发现。讲座将由邀请的演讲者和选定的海报展示，并大力推广该领域的初级研究人员。主题将从微生物扩展到人类，跨越生物重要性的多个要素。