Conference on Mouse Models of Cancer

小鼠癌症模型会议

• 批准号: 6649643
• 负责人: RONALD ANTHONY DEPINHO
• 金额: $ 1.5万
• 依托单位: AMERICAN ASSOCIATION FOR CANCER RESEARCH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-19 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6649643
• 关键词: disease /disorder model; health science research; laboratory mouse; meeting /conference /symposium; model design /development; neoplasm /cancer; travel

DESCRIPTION (provided by applicant): The aim of this proposal is to organize a scientific meeting entitled "Mouse Models for Cancer" at Disney's Contemporary Resort, Lake Buena Vista, Florida, from February 19-23, 2003. This American Association for Cancer Research (AACR) Special Conference is the third in a series of highly successful meeting on this topic. The major objectives of the meeting are: 1) to provide an overview of the field of mouse models for cancer by national and international experts; 2) To focus on new technical developments in the generation and utilization of mouse models; and 3) To provide a forum for interaction between scientists from different disciplines interested in developing and utilizing mouse models for cancer research. Animal models for human diseases are of crucial importance not only to understand the genetic factors that influence the phenotypic characteristics of the disease but also to utilize as a basis for developing rational intervention strategies. The last decade has witnessed an explosive increase in the development and characterization of mouse models for cancer. The first-generation mono-allelic cancer-prone models have been replaced by complex compound conditional TS gene knockouts/ transgenics that permit a more precise recapitulation of the temporal and spatial events in human cancer genesis, progression and maintenance. These advanced models are currently being coupled with novel noninvasive imaging modalities that enhance their suitability for preclinical testing of anti-oncologic lead compounds. Such systems hold significant promise in accelerating and making more accurate the evaluation of these compounds prior to entry into the clinic.

描述（由申请人提供）：本提案的目的是于2003年2月19日至23日在佛罗里达布埃纳维斯塔湖的迪士尼当代度假村组织一次题为“癌症小鼠模型”的科学会议。 这次美国癌症研究协会（AACR）特别会议是关于这一主题的一系列非常成功的会议中的第三次。 会议的主要目标是：1）由国家和国际专家提供癌症小鼠模型领域的概述; 2）关注小鼠模型生成和利用方面的新技术发展; 3）为来自不同学科的科学家提供一个对开发和利用癌症研究小鼠模型感兴趣的互动论坛。 人类疾病的动物模型不仅对了解影响疾病表型特征的遗传因素至关重要，而且还可用作制定合理干预策略的基础。 在过去的十年中，癌症小鼠模型的开发和表征呈爆炸式增长。 第一代单等位基因癌症易感模型已被复杂的复合条件性TS基因敲除/转基因所取代，其允许更精确地再现人类癌症发生、进展和维持中的时间和空间事件。 这些先进的模型目前正在与新的非侵入性成像方式相结合，以增强其抗肿瘤先导化合物临床前测试的适用性。 这样的系统在进入临床之前加速和更准确地评估这些化合物方面具有重要的前景。