Axonal Connections: Cues for Development & Regeneration

轴突连接：发展的线索

• 批准号: 6581616
• 负责人: John G Flanagan
• 金额: $ 3.11万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6581616
• 关键词: axon; developmental neurobiology; meeting /conference /symposium; nervous system regeneration; neuronal guidance; travel

DESCRIPTION (provided by applicant): The functioning of the nervous system depends on its complex pattern of connections. Axonal connections are initially set up during development by cues, which guide axons along specific pathways and then specify connection sites within the target region. In recent years, dramatic progress has been made in identifying such cues molecularly. Based on this progress, current studies are elucidating the molecular logic of extracellular signals that set up connectivity, as well as intracellular pathways that interpret these signals. In the adult central nervous system, damaged axonal connections do not regenerate, even though peripheral nerves can regenerate efficiently. This is due at least in part to CNS inhibitors, some of which have now been cloned. This meeting will bring together the fields of development and regeneration, with the goal of facilitating synergistic overlaps in techniques, molecules and biology. Topics will include basic research on molecular cues, and resulting new approaches toward therapeutic axon repair.

描述（由申请人提供）：神经系统的功能取决于其复杂的连接模式。 轴突连接最初是在发育过程中通过线索建立的，线索引导轴突沿着沿着特定的通路，然后在目标区域内指定连接位点。 近年来，在分子水平上识别这些线索方面取得了巨大进展。 基于这一进展，目前的研究正在阐明建立连接的细胞外信号的分子逻辑，以及解释这些信号的细胞内途径。 在成人中枢神经系统中，受损的轴突连接不能再生，即使周围神经可以有效地再生。 这至少部分是由于中枢神经系统抑制剂，其中一些现已被克隆。 这次会议将汇集发展和再生领域，以促进技术，分子和生物学的协同重叠为目标。 主题将包括分子线索的基础研究，以及由此产生的治疗轴突修复的新方法。