Evaluation of nitrated-chemokines to monitor ischaemia reperfusion injury in organ transplantation

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There is an unmet need to improve the number and quality of organs transplanted. The stress following lack of oxygen and when blood supply is reinstated results in production of molecules which modify the proteins involved in inflammation, called chemokines. These modified chemokines could be novel biomarkers in assessing organ quality before transplantation. We have developed a novel antibody for modified-chemokine; we will quantify the ratio of native to modified-chemokine in transplant patient samples. We will also use a second detection method using mass spectrometry in order to corroborate the results. This will allow transplant patient stratification.