Structural studies of the RAD6/RAD18 complex
Structural studies of the RAD6/RAD18 complex
批准号:
6584024
负责人:
SACHA N ULJON
金额:
$3.87万
依托单位国家:
美国
项目类别:
财政年份:
2003
资助国家:
美国
项目状态:
已结题
起止时间:
2003-07-01 至 2006-06-30
中文摘要
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英文摘要
DESCRIPTION (provided by applicant): Ultraviolet light damages cellular DNA, primarily by forming dimers between pyrimidine base pairs. UV-induced DNA repair mechanisms are responsible for correcting this DNA damage and preventing cancer formation. The RAD6/RAD18 complex is the central director of these UV-induced DNA repair mechanisms. RAD18 binds damaged DNA, RAD6 binds RAD18, and the complex induces both error-free and error-prone mechanisms of DNA repair. My aim is to determine the structure of the RAD6/RAD18 heterodimeric complex using X-ray crystallographic methods.
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会议论文
The Tribbles-COP1 Complex in Leukemia
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批准号:8581412
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项目类别:
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资助金额:$17.82万
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财政年份:2013
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负责人:SACHA N ULJON
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依托单位:
The Tribbles-COP1 Complex in Leukemia
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批准号:9308876
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项目类别:
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资助金额:$17.82万
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财政年份:2013
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负责人:SACHA N ULJON
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依托单位:
The Tribbles-COP1 Complex in Leukemia
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批准号:8867168
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项目类别:
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资助金额:$17.82万
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财政年份:2013
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负责人:SACHA N ULJON
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依托单位:
The Tribbles-COP1 Complex in Leukemia
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批准号:8703641
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项目类别:
-
资助金额:$17.82万
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财政年份:2013
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负责人:SACHA N ULJON
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依托单位:
Structural studies of the RAD6/RAD18 complex
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批准号:6791399
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项目类别:
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资助金额:$4.13万
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财政年份:2003
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负责人:SACHA N ULJON
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依托单位:
海外基金