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Structural studies of the RAD6/RAD18 complex

Structural studies of the RAD6/RAD18 complex
RAD6/RAD18 复合物的结构研究
批准号:
6584024
负责人:
SACHA N ULJON
金额:
$3.87万
依托单位国家:
美国
项目类别:
财政年份:
2003
资助国家:
美国
项目状态:
已结题
起止时间:
2003-07-01 至 2006-06-30

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英文摘要
DESCRIPTION (provided by applicant): Ultraviolet light damages cellular DNA, primarily by forming dimers between pyrimidine base pairs. UV-induced DNA repair mechanisms are responsible for correcting this DNA damage and preventing cancer formation. The RAD6/RAD18 complex is the central director of these UV-induced DNA repair mechanisms. RAD18 binds damaged DNA, RAD6 binds RAD18, and the complex induces both error-free and error-prone mechanisms of DNA repair. My aim is to determine the structure of the RAD6/RAD18 heterodimeric complex using X-ray crystallographic methods.
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The Tribbles-COP1 Complex in Leukemia
  • 批准号:
    8581412
  • 项目类别:
  • 资助金额:
    $17.82万
  • 财政年份:
    2013
  • 负责人:
    SACHA N ULJON
  • 依托单位:
The Tribbles-COP1 Complex in Leukemia
  • 批准号:
    9308876
  • 项目类别:
  • 资助金额:
    $17.82万
  • 财政年份:
    2013
  • 负责人:
    SACHA N ULJON
  • 依托单位:
The Tribbles-COP1 Complex in Leukemia
  • 批准号:
    8867168
  • 项目类别:
  • 资助金额:
    $17.82万
  • 财政年份:
    2013
  • 负责人:
    SACHA N ULJON
  • 依托单位:
The Tribbles-COP1 Complex in Leukemia
  • 批准号:
    8703641
  • 项目类别:
  • 资助金额:
    $17.82万
  • 财政年份:
    2013
  • 负责人:
    SACHA N ULJON
  • 依托单位:
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