Estrogens Regulate HMGA 1 and HMGA 2 in Uterine Diseases

描述（申请人提供）：子宫平滑肌瘤，又称子宫肌瘤，是女性最常见的盆腔肿瘤，雌激素在平滑肌瘤的生长发育中起重要作用已被公认。遗传因素，如染色体异常hmga1和hmga2，被发现不仅在子宫平滑肌瘤中增加，而且在其他激素相关疾病如前列腺癌、宫颈癌和乳腺癌中也增加。虽然hmga1和hmga2与激素依赖性癌有关，但它们与雌激素的相关性尚不清楚。因此，在本提案中，我们首先想确定雌激素调节子宫平滑肌瘤中的HMGA。接下来，我们计划研究环境雌激素的作用，以及雌激素通过HMGA参与子宫平滑肌瘤发展/调节的分子机制。

DESCRIPTION (provided by applicant): Uterine Leiomyomas, also called flbroids, are the most common pelvic tumors in women and it is well accepted that estrogen plays an important role in the growth and development of leiomyomas. Genetic factors, such as chromosomal abnormalitites HMGA 1 and HMGA 2, have been found to be increased in not only uterine leiomyomas but also in other hormone related diseases such as prostate, cervical, and breast cancer. Though HMGA 1 and HMGA 2 are linked to hormone dependent carcinomas, their correlation with estrogen is yet unknown. Therefore in this proposal, we first want to establish that estrogen regulates HMGA's in uterine leiomyomas. We then plan to investigate the effects of environmental estrogens and the molecular mechanisms underlying estrogen's role in the development/regulation of uterine leiomyomas through HMGA's.