Estrogens Regulate HMGA 1 and HMGA 2 in Uterine Diseases

描述（由申请人提供）：子宫平滑肌瘤，也称为纤维样瘤，是女性最常见的盆腔肿瘤，雌激素在平滑肌瘤的生长和发育中起重要作用已被广泛接受。遗传因素，如染色体异常HMGA 1和HMGA 2，已被发现不仅在子宫平滑肌瘤中增加，而且在其他激素相关疾病如前列腺癌、宫颈癌和乳腺癌中也增加。虽然HMGA 1和HMGA 2与激素依赖性癌有关，但它们与雌激素的相关性尚不清楚。因此，在这个建议中，我们首先要确定雌激素调节子宫肌瘤中的HMGA。然后，我们计划调查环境雌激素的影响和雌激素的作用下的发展/通过HMGA的子宫平滑肌瘤的调节的分子机制。

DESCRIPTION (provided by applicant): Uterine Leiomyomas, also called flbroids, are the most common pelvic tumors in women and it is well accepted that estrogen plays an important role in the growth and development of leiomyomas. Genetic factors, such as chromosomal abnormalitites HMGA 1 and HMGA 2, have been found to be increased in not only uterine leiomyomas but also in other hormone related diseases such as prostate, cervical, and breast cancer. Though HMGA 1 and HMGA 2 are linked to hormone dependent carcinomas, their correlation with estrogen is yet unknown. Therefore in this proposal, we first want to establish that estrogen regulates HMGA's in uterine leiomyomas. We then plan to investigate the effects of environmental estrogens and the molecular mechanisms underlying estrogen's role in the development/regulation of uterine leiomyomas through HMGA's.