Estrogens Regulate HMGA 1 and HMGA 2 in Uterine Diseases

描述(申请人提供)：子宫肌瘤，也被称为子宫肌瘤，是女性最常见的盆腔肿瘤，人们普遍认为雌激素在肌瘤的生长和发展中起着重要作用。遗传因素，如染色体异常HMGA 1和HMGA 2，不仅在子宫肌瘤中被发现增加，而且在其他与激素相关的疾病中也被发现增加，如前列腺癌、宫颈癌和乳腺癌。虽然HMGA 1和HMGA 2与激素依赖型癌症有关，但它们与雌激素的相关性尚不清楚。因此，在这项提案中，我们首先想要确定雌激素调节子宫肌瘤中的HMGA。然后，我们计划通过HMGA来研究环境雌激素的影响以及雌激素在子宫肌瘤发生/调节中的作用的分子机制。

DESCRIPTION (provided by applicant): Uterine Leiomyomas, also called flbroids, are the most common pelvic tumors in women and it is well accepted that estrogen plays an important role in the growth and development of leiomyomas. Genetic factors, such as chromosomal abnormalitites HMGA 1 and HMGA 2, have been found to be increased in not only uterine leiomyomas but also in other hormone related diseases such as prostate, cervical, and breast cancer. Though HMGA 1 and HMGA 2 are linked to hormone dependent carcinomas, their correlation with estrogen is yet unknown. Therefore in this proposal, we first want to establish that estrogen regulates HMGA's in uterine leiomyomas. We then plan to investigate the effects of environmental estrogens and the molecular mechanisms underlying estrogen's role in the development/regulation of uterine leiomyomas through HMGA's.