Oral Link to Vascular Disease in a HIV-1 Cohort

HIV-1 群体中口腔与血管疾病的联系

• 批准号: 6843470
• 负责人: LANCE T. VERNON
• 金额: $ 12.74万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-02 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6843470
• 关键词: AIDS therapy; Bacteroides gingivalis; HIV infections; Treponema; acute phase protein; antiviral agents; atherosclerosis; cardiovascular disorder risk; chronic disease /disorder; clinical research; combination chemotherapy; disease /disorder etiology; drug adverse effect; human immunodeficiency virus 1; human subject; inflammation; longitudinal human study; oral bacteria; oral health; patient oriented research; periodontium disorder; vascular endothelium

DESCRIPTION (provided by applicant): The applicant is a dentist committed to establishing a career investigating the connection between oral pathogens and systemic disease. His long-term goal is to characterize this connection, and to define its pathophysiology. The investigator hypothesizes that current treatment of HIV-1 infected persons with the use of highly active anti-retroviral therapy (HAART) will place these patients at higher risk for developing atherosclerosis, as mediated through metabolic complications of these agents. The candidate plans to develop and follow a longitudinal cohort of 100 HIV-1 infected patients for two years. He will examine the connection between periodontal pathogens and the development of endothelial dysfunction, a sub-clinical marker of atherosclerosis. Examining this relationship in a cohort of HIV-1 infected persons may allow for significant relationships to be detected more rapidly if, as suspected, HIV-1 infection and/or its treatment accelerates the development of atherosclerotic disease. He proposes that the relationship between oral pathogens and vascular disease within a HIV-1 population on HAART will be significantly correlated. This is the first study to examine this topic using this population of unique subjects and using measurements this sensitive and specific. The proposed research development plan will train the applicant to obtain a more in depth understanding of quantitative epidemiology, oral microbiology, atherosclerosis, and HIV/AIDS. A collaborative team of mentors and consultants has been assembled mostly within the immediate campus of Case Western Reserve University (CWRU). Primary sponsors are established NIH investigators, and each co-sponsor has expertise in their related facet of the study. Given the multidisciplinary nature of his project, this training environment is ideally suited to help the candidate meet his project and career goals. This career development plan will establish the applicant as an independent investigator poised to achieve his long-term goals. In light of the high prevalence of periodontal disease and cardiovascular disease (CAD) within the United States, this study, which proposes to clarify the relationship between oral microbiology and vascular pathology, could have profound implications on containing risk factors for CAD.

描述（由申请人提供）：申请人是一名牙医，致力于建立职业，研究口腔病原体与全身性疾病之间的联系。他的长期目标是表征这种联系，并定义其病理生理学。研究者假设使用高度活跃的抗逆转录病毒疗法（HAART）当前对HIV-1感染者的治疗将使这些患者患有较高的发生动脉粥样硬化的风险，因为这些药物的代谢并发症介导。候选人计划开发并遵循两年的100例HIV-1感染患者的纵向队列。他将检查牙周病原体与内皮功能障碍的发展（动脉粥样硬化的亚临床标记）之间的联系。如果怀疑HIV-1感染和/或其治疗加速了动脉粥样硬化疾病的发展，则在受HIV-1感染的人群中检查这种关系可能会更快地检测到重大关系。他提出，HAART HIV-1人群中口腔病原体与血管疾病之间的关系将显着相关。这是第一个使用独特主题人群检查该主题的研究，并使用该敏感和特定的测量进行了测量。 拟议的研究开发计划将培训申请人，以更深入地了解定量流行病学，口腔微生物学，动脉粥样硬化和HIV/AIDS。 一支由导师和顾问的合作团队主要集成在Case Western Reserve University（CWRU）的校园内。主要赞助商是NIH研究人员，每个共同发起人在研究的相关方面都有专业知识。鉴于他的项目的多学科性质，这种培训环境非常适合帮助候选人实现他的项目和职业目标。 这项职业发展计划将确立申请人作为一个独立的研究人员，他们准备实现长期目标。鉴于美国牙周疾病和心血管疾病（CAD）的高患病率，这项研究建议阐明口腔微生物学和血管病理学之间的关系，可能对包含CAD的危险因素具有深远的影响。