Clinical Research in Human Fertility

该申请提出了一个为期五年的计划，整合研究，教育和教学，以培养人类生育的人口，临床和行为方面的多学科研究技能。这个奖将。在来自多个学科和观点的知名科学家的指导下，为申请人提供强化培训和指导。申请的具体目的是（1）加强候选人的研究培训，以研究月经周期中受孕概率标志物的临床应用，以实现正常生育力和亚生育力的妊娠;（2）获得人口统计学方法，流行病学方法和行为科学研究方法的深入培训，因为它们与人类生育的临床和人口方面有关，（3）接受有关人类生育伦理问题的正规培训。培训计划包括（1）课程工作，（2）研究，（3）参加研讨会，（4）和有针对性的教学经验。该研究计划收集数据，观察月经周期临床上可达到的最大生育能力-在已证明生育能力的夫妇中，了解正常生育和不孕症的重要信息。因此，研究计划旨在帮助候选人发展成为独立职业临床研究者所需的技能，方法和学院关系，与多学科研究团队合作研究人类生育能力。这项研究计划名为“生育意识对临床妊娠时间的影响”，是一项前瞻性随机试验，将检查一种已被证明有效的方法来确定排卵的方法的效果。（观察宫颈粘液阴道分泌物）临床妊娠时间和排卵前6天内（包括排卵）性交行为的分布，通过测量尿液中的LH确定。该项目将直接临床相关的夫妇正常生育寻求时间的概念尽可能准确。这也将有助于指导未来的研究，以更准确地描述亚生殖力和不孕症。研究活动，沿着人口统计学方法，流行病学方法，行为科学研究方法和伦理学的先进研究，将提供作为一个成功的，独立的临床研究者终身职业所需的专业知识。 斯坦福大学的长期目标是在人类生育的临床、人口统计学和行为方面的最终交叉点上开发一个研究项目。 这一目标将通过在犹他州大学继续和推进教师角色，与多个学科的同事和学生合作来实现。 犹他州大学是一个主要的研究机构，拥有许多杰出的科学家，为斯坦福博士提供了一个良好的环境，以发展他的技能，并获得完成他的目标所需的专业知识。

This application proposes a five-year program integrating research, education, and teaching to develop skills for multidisciplinary research in demographic, clinical and behavioral aspects of human fertility. This award will. provide the applicant with intensive training and mentoring under the guidance of established scientists from multiple disciplines and perspectives. The specific aims of the application are (1) to enhance the candidate's research training to study the clinical application of markers of the probability of conception in the menstrual cycle to achieve pregnancy in normal fecundity and subfecundity; (2) to acquire in-depth training in demographic methods, epidemiologic methods, and behavioral science research methods as they relate to clinical and population dimensions of human fertility, and (3) to obtain formal training in ethical issues in human fertility. The training plan includes (1) course work, (2) research, (3) participation in seminars, (4) and targeted teaching experiences. The research plan collects data to observe the maximum clinically attainable fecundability of the menstrual cycle -in couples of proven fertility, information of importance for understanding normal fertility and infertility. Thus the research plan is designed to help the candidate to develop skills, methods, and collegial relationships needed to become an independent career clinical investigator working with multidisciplinary research teams to study human fertility. The research plan, "Effect of fertility awareness on time to clinical pregnancy," is a prospective randomized trial which will examine the effect of a proven method of identifying the approach of ovulation (the observation of vaginal discharge of mucus from the uterine cervix) on time to clinical pregnancy and distribution of acts of intercourse within a 6-day time period preceding and including ovulation, as determined by the measurement of LH in the urine. The project will be of immediate clinical relevance to couples of normal fertility seeking to time conception as precisely as possible. It will also help guide future research to more precisely describe subfecundity and infertility. The research activities, along with advanced studies of demographic methods, epidemiologic methods, behavioral science research methods, and ethics, will provide the expertise needed for a lifelong career as a successful, independent clinical investigator. Dr. Stanford's long-term goal is to develop a program of research at the end intersection of the clinical, demographic, and behavioral aspects of human fertility. This goal will be achieved by continuing and advancing in a faculty role at the University of Utah, working with colleagues and students in multiple disciplines. The University of Utah is a major research institution with many distinguished scientists which offers an excellent environment for Dr. Standford to develop his skills and gain the expertise needed to accomplish his goals.