LANGUAGE PROCESSING IN SCHIZOPHRENIA

描述：（改编自申请人的摘要）这是一个NIMH的请求 指导以患者为导向的研究职业发展奖（K-23）， “精神分裂症语言处理的认知神经科学”。 长期以来，思维和语言障碍一直被认为是 精神分裂症候选人将测试这样的语言的假设， 异常是由特定的认知和神经缺陷引起的 语义（Semantics）为了解决这个问题，她打算接受培训， 三种互补的方法。 首先，心理语言学范式将被用来定义的具体性质， 精神分裂症在认知水平上的语言处理缺陷。第二、 电生理学实验将确定时间01 精神分裂症患者语言处理过程中的神经生理异常， 通过检测N400-事件相关电位的潜伏期和振幅， 已知对语义上下文敏感。第三，事件相关功能磁共振成像 研究将描述语言处理的功能神经解剖学特征， 缺陷的精神分裂症，通过检查活动的时间和 下额叶皮层（特别是在左边）的区域，已知 介导语义处理。 使用这三种方法来解决同样的基本问题 将深入了解语言功能障碍的认知和神经基础 在精神分裂症中，在空间和时间域中。额外的说教 指导和专家指导，认知神经科学，心理语言学 和先进的统计，将提供理论框架和 分析工具来整合这三种方法， 概念上和数量上。该培训和研究计划将 把候选人推向舞台，使她能够确立自己的地位。 精神分裂症认知神经科学的独立研究者。

DESCRIPTION: (Adapted from applicant's abstract)This is a request for an NIMH Mentored Patient-Oriented Research Career Development Award (K-23) entitled 'The Cognitive Neuroscience of Language Processing in Schizophrenia'. A disorder of thought and language has long been considered a core feature of schizophrenia. The candidate will test the hypothesis that such language abnormalities arise from specific cognitive and neural deficits in processing meaning (semantics). To address this question, she aims to acquire training in three complementary methodologies. First, psycholinguistic paradigms will be used to define the specific nature of language processing deficits in schizophrenia at a cognitive level. Second, electrophysiological experiments will determine the timing 01 neurophysiological abnormalities during language processing in schizophrenia, by examining the latency and amplitude of the N400- an event related potential that is known to be sensitive to semantic context. Third, event-related fMRI studies will characterize the functional neuroanatomy of language processing deficits in schizophrenia, by examining activity within the temporal and the inferior frontal cortex (particularly on the left) regions that are known to mediate semantic processing. The use of these three methodologies to address the same fundamental questions will give insights into the cognitive and neural basis of language dysfunction in schizophrenia, in both spatial and temporal domains. Additional didactic instruction and expert mentorship, in cognitive neuroscience, psycholinguistics and advanced statistics, will provide the theoretical framework and the analytical tools to integrate across these three methodologies, both conceptually and quantitatively. This training and research program will advance the candidate to the stage when she can establish herself as an independent investigator of the cognitive neuroscience of schizophrenia.