LANGUAGE PROCESSING IN SCHIZOPHRENIA

描述：(改编自申请人的摘要)这是一份申请NIMH的申请书 以病人为导向的导师研究职业发展奖(K-23)，题为 《精神分裂症患者语言处理的认知神经科学》。 思维和语言的混乱一直被认为是 精神分裂症。候选人将检验这样一种语言的假设 异常是由加工过程中特定的认知和神经缺陷引起的 意义(语义)。为了解决这个问题，她的目标是在 三种相辅相成的方法。 首先，心理语言学范式将被用来定义特定的性质 精神分裂症患者认知水平的语言加工缺陷。第二, 电生理实验将确定01的时间 精神分裂症患者语言加工过程中的神经生理异常， 通过检测事件相关电位N400的潜伏期和波幅 这是众所周知的对语义语境敏感的。第三，事件相关功能磁共振 研究将描述语言处理的功能神经解剖学 精神分裂症的缺陷，通过检查颞叶和大脑中的活动 已知的额叶下部皮质(尤其是左侧) 中介语义处理。 使用这三种方法来解决相同的根本问题 将深入了解语言功能障碍的认知和神经基础 在精神分裂症中，无论是在空间领域还是在时间领域。附加说教 认知神经科学、心理语言学方面的指导和专家指导 和先进的统计数据，将提供理论框架和 用于集成这三种方法的分析工具，两者 从概念上和数量上。这项培训和研究计划将 把候选人推上舞台，当她能确立自己的地位时 精神分裂症认知神经科学的独立研究员。

DESCRIPTION: (Adapted from applicant's abstract)This is a request for an NIMH Mentored Patient-Oriented Research Career Development Award (K-23) entitled 'The Cognitive Neuroscience of Language Processing in Schizophrenia'. A disorder of thought and language has long been considered a core feature of schizophrenia. The candidate will test the hypothesis that such language abnormalities arise from specific cognitive and neural deficits in processing meaning (semantics). To address this question, she aims to acquire training in three complementary methodologies. First, psycholinguistic paradigms will be used to define the specific nature of language processing deficits in schizophrenia at a cognitive level. Second, electrophysiological experiments will determine the timing 01 neurophysiological abnormalities during language processing in schizophrenia, by examining the latency and amplitude of the N400- an event related potential that is known to be sensitive to semantic context. Third, event-related fMRI studies will characterize the functional neuroanatomy of language processing deficits in schizophrenia, by examining activity within the temporal and the inferior frontal cortex (particularly on the left) regions that are known to mediate semantic processing. The use of these three methodologies to address the same fundamental questions will give insights into the cognitive and neural basis of language dysfunction in schizophrenia, in both spatial and temporal domains. Additional didactic instruction and expert mentorship, in cognitive neuroscience, psycholinguistics and advanced statistics, will provide the theoretical framework and the analytical tools to integrate across these three methodologies, both conceptually and quantitatively. This training and research program will advance the candidate to the stage when she can establish herself as an independent investigator of the cognitive neuroscience of schizophrenia.