Spatiotemporal imaging of language in schizophrenia

精神分裂症语言的时空成像

• 批准号: 6985095
• 负责人: GINA R KUPERBERG
• 金额: $ 37.19万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6985095
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain mapping; clinical research; electrophysiology; evoked potentials; functional magnetic resonance imaging; human subject; language disorders; neural information processing; neurophysiology; patient oriented research; prefrontal lobe /cortex; psycholinguistics; schizophrenia; semantics; temporal lobe /cortex

A disorder of thought and language has long been considered a core feature of schizophrenia. The broad objective of this proposal is to identify abnormalities in the neural dynamics of language processing in schizophrenia using multimodal imaging techniques. It is hypothesized that abnormally increased neural/synaptic activity within a temporal-prefrontal network (left superior and middle temporal, bilateral inferior temporal and left inferior prefrontal cortices) to semantic relationships between individual words leads to abnormal modulation of temporal-prefrontal activity as context is built up, word by word, within and across sentences. This cognitive neurobiological theory of language dysfunction in schizophrenia will be tested in a series of experiments studying (a) semantic relationships between word pairs, (b) the build up of context within sentences and (c) contextual integration across sentences (discourse). In order to investigate "when" and "where", a multimodal approach will be taken, integrating the advantages of two complementary neuroimaging techniques. First, electrophysiological experiments will determine the time course of neurocognitive abnormalities during language processing in schizophrenia by examining the N400 and late positive components - event related potentials that are known to be sensitive to contextual integration. Second, event-related functional (magnetic resonance imaging studies will characterize the functional neuroanatomy of language abnormalities in schizophrenia by examining the extent, magnitude and temporal dynamics of the hemodynamic response within the temporal-prefrontal semantic network. Third, data obtained using these complementary techniques will be directly compared, allowing inferences to be made about underlying neural/synaptic activity, and quantitatively combined, allowing the delineation of spatiotemporal patterns of activation across temporal and prefrontal cortices during language processing in schizophrenia.

长期以来，思维和语言障碍一直被认为是精神分裂症的核心特征。这项建议的主要目的是确定异常的神经动力学的语言处理精神分裂症使用多模态成像技术。据推测，异常增加的神经/突触活动的颞-前额叶网络（左上级和中颞，双侧颞下和左下前额叶皮质）的语义关系之间的个别单词导致异常调制的颞-前额叶活动的上下文建立，一个词接一个词，在句子内和跨句子。精神分裂症语言功能障碍的认知神经生物学理论将在一系列实验中进行测试，这些实验研究（a）单词对之间的语义关系，（B）句子内上下文的建立和（c）跨句子（话语）的上下文整合。为了调查“何时”和“何地”，将采取多模态方法，整合两种互补的神经成像技术的优势。首先，电生理学实验将通过检查N400和晚期阳性成分-已知对上下文整合敏感的事件相关电位来确定精神分裂症语言处理期间神经认知异常的时间过程。第二，事件相关功能（磁共振成像研究将通过检查颞-前额叶语义网络内血流动力学反应的范围、幅度和时间动态来表征精神分裂症语言异常的功能神经解剖学。第三，使用这些互补技术获得的数据将直接进行比较，从而可以对潜在的神经/突触活动进行推断，并定量结合，从而可以描绘精神分裂症语言处理过程中颞叶和前额叶皮层激活的时空模式。