Tobacco abstinence-induced cognitive decrements

描述（由申请人提供）： 许多吸烟者报告说，他们在戒烟尝试期间难以集中注意力，这表明认知能力下降可能是戒烟的一个特征。尼古丁替代疗法（NRT）在改善这种减少方面的有效性尚不清楚。此外，NRT在改善禁欲引起的认知减退方面的有效性可能在男性和女性之间存在差异。为了检查NRT改善与禁欲相关的认知减退的能力，并检查NRT的性别特异性效应，男性（N =64）和女性（N = 64）吸烟者将参加一项四阶段的受试者内研究。在每个阶段中，12小时剥夺吸烟者将接受四种剂量的尼古丁透皮吸收（0、7、21和42 mg）中的一种，并在接下来的4小时内保持戒烟。在最后两个小时内，他们每30分钟吸一支烟。注意力和工作记忆（以及其他结果）将被评估。研究结果将有助于阐明戒烟对认知的影响，也将揭示纯尼古丁、烟草中尼古丁和性别对戒烟引起的认知减退的影响。非认知方法学研究的细节在R01 DA011082（T. Pl. Pl.）。

DESCRIPTION (provided by applicant): Many smokers report that they experience difficulty concentrating during a quit-attempt, suggesting that cognitive decrements may be a feature of tobacco abstinence. The effectiveness of nicotine replacement therapy (NRT) in ameliorating such decrements is not clear. In addition, NRT's effectiveness in ameliorating abstinence-induced cognitive decrements may differ between men and women. To examine NRT's ability to ameliorate cognitive decrements associated with abstinence, and to examine gender specific effects of NRT, male (N =64) and female (N = 64) smokers will participate in a four-session, within-subject study. In each of session, 12-hour deprived smokers will receive one of four doses of transdermal nicotine (0, 7, 21, and 42 mg) and will remain tobacco-abstinent for the next 4 hours. For the last two hours, they will smoke one cigarette every 30 min. Attention and working memory (and other outcomes) will be assessed. Results will help clarify the effect of tobacco abstinence on cognition, and will also reveal the effects of pharmacologically pure nicotine, tobacco cigarette-delivered nicotine, and gender on abstinence-induced cognitive decrements. Non-cognitive methdolological study details were described in, and are funded by, R01 DA011082 (T. Eissenberg, PI).