Tobacco abstinence-induced cognitive decrements

描述(由申请人提供)： 许多吸烟者报告说，他们在戒烟期间遇到了集中注意力的困难，这表明认知能力下降可能是烟草戒断的一个特征。尼古丁替代疗法(NRT)在改善这种减少方面的有效性尚不清楚。此外，NRT在改善禁欲引起的认知减退方面的有效性可能因男性和女性而异。为了检验NRT改善与戒烟相关的认知减退的能力，并检验NRT对性别的影响，男性(N=)和女性(N=)吸烟者将参加一项为期四个疗程的受试者内研究。在每个疗程中，禁烟12小时的吸烟者将获得四种剂量(0、7、21和42毫克)中的一种透皮尼古丁，并在接下来的4小时内保持戒烟状态。在过去的两个小时里，他们将每30分钟抽一支烟。将对注意力和工作记忆(以及其他结果)进行评估。结果将有助于阐明烟草戒断对认知的影响，还将揭示药理纯尼古丁、烟草香烟传递的尼古丁和性别对戒烟诱导的认知减退的影响。非认知方法学研究的细节在R01 DA011082(T.Eissenberg，PI)中描述，并由其资助。

DESCRIPTION (provided by applicant): Many smokers report that they experience difficulty concentrating during a quit-attempt, suggesting that cognitive decrements may be a feature of tobacco abstinence. The effectiveness of nicotine replacement therapy (NRT) in ameliorating such decrements is not clear. In addition, NRT's effectiveness in ameliorating abstinence-induced cognitive decrements may differ between men and women. To examine NRT's ability to ameliorate cognitive decrements associated with abstinence, and to examine gender specific effects of NRT, male (N =64) and female (N = 64) smokers will participate in a four-session, within-subject study. In each of session, 12-hour deprived smokers will receive one of four doses of transdermal nicotine (0, 7, 21, and 42 mg) and will remain tobacco-abstinent for the next 4 hours. For the last two hours, they will smoke one cigarette every 30 min. Attention and working memory (and other outcomes) will be assessed. Results will help clarify the effect of tobacco abstinence on cognition, and will also reveal the effects of pharmacologically pure nicotine, tobacco cigarette-delivered nicotine, and gender on abstinence-induced cognitive decrements. Non-cognitive methdolological study details were described in, and are funded by, R01 DA011082 (T. Eissenberg, PI).