Prevention &Treatment of HIV/AIDS in Adults and Children

预防

• 批准号: 6730133
• 负责人: ALEXANDER S CHERNOV
• 金额: $ 5.39万
• 依托单位: TOMSK REG CTR/PREVENTION & TREATMENT
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6730133
• 关键词: AIDS education /prevention; AIDS therapy; Commonwealth of Independent States; HIV infections; Mycobacterium tuberculosis; comorbidity; ethics; microorganism disease chemotherapy; placental transfer; prenatal care; statistics /biometry; training; vertical transmission

DESCRIPTION (provided by applicant): Specific Aims. The goal of this proposal is to enable the Tomsk Regional Center for AIDS and other Infectious Diseases (TRCAID) to (1) plan and develop a comprehensive HIV/AIDS prevention and treatment research agenda relevant to its patient population and (2) enhance the infrastructure necessary for the Center to conduct such research. The result will be to develop a CIPRA U01 grant application in approximately two years. R03 funding will allow the TRCAID to develop additional institutional infrastructure and provide appropriate training as well as begin the process of data collection and research design necessary to achieve that goal. Background and Significance. The AIDS epidemic is spreading faster in the former Soviet bloc than anywhere else in the world. The Tomsk Oblast, in southwestern Siberia, where the epidemiological impact of HIV, TB, and STDs is much worse than for the European part of Russia. TRCAID is the best-equipped facility in the region to address the NIAID CIPRA priorities and develop independent research capability. Research Design and Methods. This planning grant will use three strategies: (1) creation of an External Advisory Committee composed of (a) faculty at Baylor College of Medicine in Houston, Texas, and local and regional healthcare leaders in Tomsk. The Baylor faculty will mentor the TRCAID personnel who will develop a functioning research infrastructure over the next two years. The Russian advisors will provide links to the local and federal ministries of health so that TRCAID can effectively implement the training and suggestions provided by the address the tasks necessary to build a research infrastructure at TRCAID; and (3) a process of learning by doing, by which TRCAID staff will be mentored as they develop plans for the CIPRA U01 application that will be submitted in two years. The project will provide professional development related to (1) prevention and treatment of HIV/AIDS according to current WHO and western standards; (2) medical ethics, protection of human subjects, and establishment of an institutional review board (IRB) for protection of human subjects; (3) biostatistics and research design; and (4) English language training for designated TRCAID staff and investigators directly involved in the current R03 and anticipated U01 projects. TRCAID staff will design a research project related to prevention of mother-to-child-transmission (MTCT), including assessment of HIV and barriers to prenatal care in Tomsk Region and development of targeted patient education materials. TRCAID will also identify appropriate and optimal HIV/AIDS drug regimens and ascertain their availability, especially in the context of HIV-associated co-morbid infections such as mycobacterium tuberculosis. Over the two years of the grant, there will be approximately 15 exchange visits between Tomsk and Houston.

描述（由申请人提供）：具体目的。该提案的目的是使汤姆斯克艾滋病和其他传染病区域中心（TRCAID）能够（1）计划并开发与患者人群有关的全面的艾滋病毒/艾滋病预防和治疗研究议程，以及（2）增强对中心进行此类研究所必需的基础设施。结果将是在大约两年内开发CIPRA U01赠款申请。 R03资金将使TRCAID能够开发其他机构基础设施，并提供适当的培训，并开始实现该目标所必需的数据收集和研究设计过程。背景和意义。艾滋病的流行在前苏联集团中的传播速度比世界其他任何地方都要快。汤姆斯克（Tomsk）在西伯利亚西南部的汤姆斯克（Tomsk）持续状态，艾滋病毒，结核病和性病的流行病学影响比俄罗斯的欧洲地区差得多。 TRCAID是该地区设备齐全的设施，旨在解决NIAID CIPRA优先事项并发展独立的研究能力。研究设计和方法。该计划赠款将采用三种策略：（1）由（a）德克萨斯州休斯顿贝勒医学院的教职员工以及汤姆斯克的地方和地区医疗保健领导者组成的外部咨询委员会。贝勒教职员工将指导Trcaid人员，他们将在未来两年内开发出正常的研究基础设施。俄罗斯顾问将提供与地方和联邦卫生部的联系，以便TRCAID可以有效地实施在TRCAID上建立研究基础设施所需的任务所提供的培训和建议； （3）通过执行学习过程，在制定CIPRA U01申请计划的计划中将在两年内提交的CIPRA U01申请计划。该项目将根据当前和西方标准提供与（1）预防和治疗艾滋病毒/艾滋病有关的专业发展； （2）医学伦理，保护人类受试者以及建立一个保护人类受试者的机构审查委员会（IRB）； （3）生物统计学和研究设计； （4）针对指定的TRCAID人员和调查人员直接参与当前R03和预期U01项目的英语培训。 TRCAID工作人员将设计一个与预防母亲转变（MTCT）有关的研究项目，包括评估艾滋病毒和汤姆斯克地区的产前护理障碍以及有针对性的患者教育材料的开发。 TRCAID还将确定适当和最佳的HIV/AIDS药物方案并确定其可用性，尤其是在与HIV相关的合并感染（如结核分枝杆菌）的情况下。在赠款的两年中，汤姆斯克和休斯顿之间将大约有15次交换访问。