Pancreas cancer analysis-SF Bay Area case-control study

胰腺癌分析-旧金山湾区病例对照研究

• 批准号: 6840932
• 负责人: ELIZABETH A. HOLLY
• 金额: $ 7.58万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-09 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6840932
• 关键词: DNA repair; alcoholic beverage consumption; behavioral /social science research tag; cancer risk; chemical carcinogen; clinical research; cytochrome P450; data collection methodology /evaluation; diabetes mellitus; drug metabolism; estrogens; gene environment interaction; genetic polymorphism; genetic susceptibility; glutathione transferase; health behavior; hormone related neoplasm /cancer; human data; mathematical model; neoplasm /cancer epidemiology; nutrition related neoplasm /cancer; pancreas neoplasms; pancreatitis; smoking; women' s health

DESCRIPTION (provided by applicant): Pancreas cancer analysis-SF Bay Area case-control study: Pancreatic cancer (PC) is the fourth most common cause of cancer death with the lowest 5-year survival rate (<5%) of all cancers. It has been designated as a high priority for NCI by the NCI-sponsored Progress Review Group and by Congress for FY 2004. The overall study goal is to continue data analyses for our large population-based case-control study of PC that was conducted between 1994 and 2002 (no proxy interviews, n=532 patients, 1701 controls). Using unconditional logistic regression, the specific aims are to: 1) perform data analyses of diet (energy-adjusted for nutrients), pancreatitis, diabetes, smoking, alcohol consumption, and hormone use in women in relation to PC; and 2) to evaluate the relationships between factors in Aim 1 and previously determined polymorphisms (GSTT1, GSTM1, CYPIA1, XRCC1). Detailed data were collected for this study about each factor of interest. Because the genes of interest play an important role in detoxification of carcinogenic polycyclic aromatic hydrocarbons and heterocyclic amines, estrogen metabolism and repair of DNA damaged by oxidative stress, it is plausible that the presence of polymorphisms in these genes will alter the association between pancreatic cancer and factors in Aim 1. Study strengths include: 1) already identified genetic polymorphisms; 2) extensive information on risk factors; 3) diet questionnaire developed by Dr. Walter Willett's group at Harvard University who have computed macro and micronutrients for this study; 4) large sample size allows combination of risk-factor and molecular data to determine possible interactions between genetic and environmental factors; 5) data were collected on food preparation methods and vitamins that may be relevant in PC etiology; 6) SEER registry provided complete case ascertainment; and 7) can evaluate potential confounding and effect modification. Data on modifiable risk factors may provide new and provocative results of 3ublic health importance for this devastating disease.

描述(由申请人提供)： 胰腺癌分析-SF Bay地区病例对照研究：胰腺癌(PC)是癌症死亡的第四大常见原因，在所有癌症中5年存活率最低(5%)。它已被NCI赞助的进度审查小组和国会指定为NCI 2004财年的高度优先事项。总体研究目标是继续我们1994至2002年间进行的基于人群的PC病例对照研究的数据分析(无代理访谈，n=532名患者，1701名对照)。使用非条件Logistic回归分析的具体目的是：1)对女性的饮食(经营养素调整的能量)、胰腺炎、糖尿病、吸烟、饮酒和激素使用与PC的关系进行数据分析；2)评估AIM 1中的因素与先前确定的基因多态(GSTT1、GSTM1、CYPIA1、XRCC1)之间的关系。为这项研究收集了关于每个感兴趣的因素的详细数据。由于感兴趣的基因在致癌多环芳烃和杂环胺的解毒、雌激素代谢和氧化应激损伤的DNA修复中发挥着重要作用，因此这些基因的多态可能会改变胰腺癌与目标1中的因素之间的关联。研究优势包括：1)已经发现的基因多态；2)关于危险因素的广泛信息；3)哈佛大学沃尔特·威莱特博士的团队为本研究计算了宏观和微量营养素的饮食调查问卷；4)大样本允许结合风险因素和分子数据来确定遗传和环境因素之间可能的相互作用；5)收集了可能与PC病因学相关的食品制备方法和维生素的数据；6)SEER登记提供了完整的病例确证；以及7)可以评估潜在的混淆和效果修改。关于可改变的危险因素的数据可能会为这种毁灭性疾病提供新的、具有挑衅性的结果，表明其对公众健康的重要性。