Prospective Nursing Study of Breast Cancer Lymphedema

乳腺癌淋巴水肿的前瞻性护理研究

• 批准号: 6733542
• 负责人: Jane M Armer
• 金额: $ 32.07万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-15 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6733542
• 关键词: breast neoplasms; female; functional ability; human subject; interview; longitudinal human study; lymphedema; measurement; patient oriented research; sign /symptom; social adjustment; social support network; women' s health

DESCRIPTION (provided by applicant): In the Western world, breast cancer and its treatment are the leading causes of lymphedema. More than two million women living with breast cancer in this country, accounting for nearly 25 percent of all cancer survivors, are at risk for development of lymphedema throughout their lifetimes. Lymphedema occurs as both an acute and chronic condition, characterized by significant persistent swelling associated with an abnormal accumulation of protein-rich fluid in the affected area. The impact of unmanaged and unresolved lymphedema on quality of life among women surviving breast cancer is extensive, encompassing interpersonal and family relationships, functional abilities, occupational roles, self-image, and self-esteem. The goal of the proposed nursing study is the description of measurement, incidence, management, and overall effect of lymphedema among women diagnosed with and treated for breast cancer and followed over 30 months. The primary aims of this study are two-fold: Aim 1: Compare the reliability and clinical validity of two measurement methods for limb fluid volume: (a) traditional circumferential arm measurement versus (b) infrared perometry, at pre-operative, postoperative, and routine follow-up points. Aim 2: Examine across time the type of symptoms experienced and functional health status of breast cancer patients with and without lymphedema. A secondary aim (Aim 3) is: Examine and compare over time the complex relations (main effects, moderators, mediators) between: (a) problem solving and social support, (b) lymphedema and coping effectiveness, and (c) post-treatment psychosocial adjustment and functional health. These aims will be met through a prospective, longitudinal design, which will support the examination of measurement, incidence, psychosocial adjustment, and health status among women treated for breast cancer through psychometrically sound face-to-face interviews, and physiological measures. Some 200 women diagnosed and subsequently treated for breast cancer will be recruited and enrolled in years 1 and 2 and followed over 30 months. The study will provide new information about the measurement of lymphedema, which is a critical issue in furthering an accurate understanding of the incidence, management, and effect of lymphedema on the lives of breast cancer patients. Findings from this investigation will also provide important information about lymphedema signs and symptoms, self-care management, and its impact on psychosocial adjustment and functional health; this information will form the basis of subsequent interventions with lymphedema patients. The results identifying more complex relationships between the physiological and psychosocial variables will guide development and testing of nursing interventions to prevent, detect, and manage post-breast cancer treatment lymphedema.

描述（由申请人提供）：在西方世界，乳腺癌和 它的治疗是引起水肿的主要原因。200多万女性 在这个国家，患有乳腺癌的人，占近25%， 所有癌症幸存者，自始至终都面临着发生淋巴水肿的风险 他们的一生淋巴水肿作为急性和慢性病症发生， 特征在于与异常的 在受影响的区域积累富含蛋白质的液体。的影响 未得到管理和解决的水肿对幸存妇女的生活质量的影响 乳腺癌是广泛的，包括人际和家庭 人际关系、功能能力、职业角色、自我形象， 自尊拟议的护理研究的目标是描述 测量，发病率，管理，和整体效果， 被诊断为乳腺癌并接受治疗的妇女，并随访了30个月。 本研究的主要目的有两个：目的1：比较可靠性和 两种肢体液体容量测量方法的临床有效性：（a） 传统的圆周臂测量与（B）红外透视测量， 术前、术后和常规随访点。目标2：检查 随着时间的推移，所经历的症状类型和功能性健康状况 乳腺癌患者伴或不伴水肿。第二个目标（目标3）是： 检查并比较随时间推移的复杂关系（主效应，调节因子， （a）解决问题和社会支持，（B）水肿和 （c）治疗后的心理社会调整， 功能性健康这些目标将通过一个前瞻性的、纵向的 设计，这将支持检查测量，发病率， 接受乳腺癌治疗妇女的心理社会适应和健康状况 癌症通过心理测量声音面对面访谈， 生理措施。大约200名妇女被诊断并随后接受治疗， 将在第1年和第2年招募并入组乳腺癌患者， 30个月这项研究将提供有关测量 水肿，这是一个关键问题，在进一步准确理解 的发病率，管理，以及对乳房水肿的生活的影响， 癌症患者。调查结果还将提供重要的 关于水肿体征和症状，自我护理管理及其 对心理社会调整和功能健康的影响;这些信息将 形成对水肿患者进行后续干预的基础。的 结果表明，在生理和 心理社会变量将指导护理的发展和测试 预防、检测和管理乳腺癌治疗后的干预措施 水肿