GAIT DYNAMICS & FUNCTIONAL ASSESSMENT OF CHRONIC DISEASE

步态动力学

• 批准号: 6777458
• 负责人: CHUNG-KANG PENG
• 金额: $ 22.95万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-14 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6777458
• 关键词: Huntington' s disease; Internet; Parkinson' s disease; adult human (21+); amyotrophic lateral sclerosis; arthritis therapy; biomechanics; brain electronic stimulator; chronic disease /disorder; computer system design /evaluation; diagnosis design /evaluation; exercise; functional ability; gait; human subject; human therapy evaluation; longitudinal human study; nervous system disorder therapy; osteoarthritis; pathologic process; patient oriented research

Preliminary work suggests that measures based on gait dynamics may be useful in assisting in the functional assessment of chronic disease and the resulting disability. Approximately forty nine million Americans have a chronic disability. These disabilities often affect physical function and mobility, limit activities, reduce independence, and decrease quality of life. However, the absence of precise, quantitative and objective measures of function that can be administered in multiple settings (e.g., in the clinic) limits our ability to objectively monitor disease progression and assess the efficacy of new therapeutic interventions. The overall goal of the present application is to extend our preliminary findings to evaluate how measures of gait dynamics may be used in functional assessment of chronic disease. Because gait dynamics may serve as a sensitive and clinically relevant index of functional ability in the evaluation of intervention trials and may be useful in augmenting early diagnosis of chronic disease, we believe it is critical to understand its origins. A secondary goal of this project, therefore, is to quantitatively characterize the factors that contribute to altered gait dynamics. The third objective of this application is to develop practical measures of gait dynamics that can be used to augment clinical assessment of chronic disabling disease. In this project, we will study the relationship between chronic disease (i.e., knee osteoarthritis, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis), gait dynamics, and functional status and evaluate how gait dynamics change with disease progression and in response to therapeutic interventions, including exercise and deep brain stimulation. The results of the study will provide new insight into the physiology and adaptations of chronic disease, the efficacy of different therapeutic interventions, and may also provide a new method to augment functional assessment of chronic disability.

初步工作表明，基于步态动力学的测量可能 可用于协助慢性病和慢性疾病的功能评估 造成的残疾。大约四千九百万美国人患有慢性病 残疾。这些残疾通常会影响身体功能和活动能力， 限制活动、减少独立性并降低生活质量。然而， 缺乏精确、定量和客观的功能测量 可以在多种环境中（例如在诊所）进行管理，限制了我们的 客观监测疾病进展和评估疗效的能力 新的治疗干预措施。本申请的总体目标是 扩展我们的初步研究结果来评估步态动力学的测量方法 可用于慢性疾病的功能评估。因为步态动力学 可以作为功能能力的敏感且临床相关的指标 干预试验的评估，可能有助于增强早期干预效果 慢性病的诊断，我们认为了解其慢性病的诊断至关重要 起源。因此，该项目的第二个目标是定量 描述导致步态动力学改变的因素。第三个 该应用程序的目标是开发步态动力学的实用测量方法 可用于增强慢性致残疾病的临床评估。 在这个项目中，我们将研究慢性疾病（即， 膝骨关节炎、帕金森病、亨廷顿病和肌萎缩症 侧索硬化症）、步态动力学和功能状态，并评估步态如何 动力学随疾病进展和治疗反应而变化 干预措施，包括运动和深部脑刺激。结果 该研究将为生理学和适应性提供新的见解 慢性疾病、不同治疗干预措施的功效，以及可能 还提供了一种新方法来增强慢性病的功能评估 残疾。