GAIT DYNAMICS & FUNCTIONAL ASSESSMENT OF CHRONIC DISEASE

初步工作表明，基于步态动力学的措施， 有助于慢性病的功能评估， 导致残疾。大约有4900万美国人患有慢性 残疾。这些残疾往往影响身体功能和行动能力， 限制活动，降低独立性，降低生活质量。然而，在这方面， 缺乏对职能准确、定量和客观的衡量， 可以在多种情况下施用（例如，在诊所）限制了我们的 客观监测疾病进展和评估 新的治疗干预措施。本申请的总体目标是 扩展我们的初步研究结果，以评估如何测量步态动力学， 可用于慢性疾病的功能评估。因为步态动力学 可以作为一个敏感的和临床相关的功能能力指标， 干预试验的评价，并可能有助于增加早期 对于慢性病的诊断，我们认为了解其 起源.因此，该项目的第二个目标是定量地 表征导致步态动力学改变的因素。第三 本申请的目的是开发步态动力学的实用措施 可以用来增强慢性致残性疾病的临床评估。 在这个项目中，我们将研究慢性疾病（即， 膝关节骨关节炎、帕金森病、亨廷顿病和肌萎缩 侧索硬化症），步态动力学和功能状态，并评估步态如何 动力学随着疾病进展而变化， 干预措施，包括运动和深部脑刺激。的结果 这项研究将为人类的生理学和适应性提供新的见解。 慢性疾病，不同治疗干预的疗效，并可能 也提供了一种新的方法，以增加功能评估慢性 残疾。

Preliminary work suggests that measures based on gait dynamics may be useful in assisting in the functional assessment of chronic disease and the resulting disability. Approximately forty nine million Americans have a chronic disability. These disabilities often affect physical function and mobility, limit activities, reduce independence, and decrease quality of life. However, the absence of precise, quantitative and objective measures of function that can be administered in multiple settings (e.g., in the clinic) limits our ability to objectively monitor disease progression and assess the efficacy of new therapeutic interventions. The overall goal of the present application is to extend our preliminary findings to evaluate how measures of gait dynamics may be used in functional assessment of chronic disease. Because gait dynamics may serve as a sensitive and clinically relevant index of functional ability in the evaluation of intervention trials and may be useful in augmenting early diagnosis of chronic disease, we believe it is critical to understand its origins. A secondary goal of this project, therefore, is to quantitatively characterize the factors that contribute to altered gait dynamics. The third objective of this application is to develop practical measures of gait dynamics that can be used to augment clinical assessment of chronic disabling disease. In this project, we will study the relationship between chronic disease (i.e., knee osteoarthritis, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis), gait dynamics, and functional status and evaluate how gait dynamics change with disease progression and in response to therapeutic interventions, including exercise and deep brain stimulation. The results of the study will provide new insight into the physiology and adaptations of chronic disease, the efficacy of different therapeutic interventions, and may also provide a new method to augment functional assessment of chronic disability.