GAIT DYNAMICS & FUNCTIONAL ASSESSMENT OF CHRONIC DISEASE

步态动力学

• 批准号: 6536267
• 负责人: CHUNG-KANG PENG
• 金额: $ 22.95万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-14 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6536267
• 关键词: Huntington's disease; Internet; Parkinson's disease; adult human (21+); amyotrophic lateral sclerosis; arthritis therapy; biomechanics; brain electronic stimulator; chronic disease /disorder; computer system design /evaluation; diagnosis design /evaluation; exercise; functional ability; gait; human subject; human therapy evaluation; longitudinal human study; nervous system disorder therapy; osteoarthritis; pathologic process; patient oriented research

Preliminary work suggests that measures based on gait dynamics may be useful in assisting in the functional assessment of chronic disease and the resulting disability. Approximately forty nine million Americans have a chronic disability. These disabilities often affect physical function and mobility, limit activities, reduce independence, and decrease quality of life. However, the absence of precise, quantitative and objective measures of function that can be administered in multiple settings (e.g., in the clinic) limits our ability to objectively monitor disease progression and assess the efficacy of new therapeutic interventions. The overall goal of the present application is to extend our preliminary findings to evaluate how measures of gait dynamics may be used in functional assessment of chronic disease. Because gait dynamics may serve as a sensitive and clinically relevant index of functional ability in the evaluation of intervention trials and may be useful in augmenting early diagnosis of chronic disease, we believe it is critical to understand its origins. A secondary goal of this project, therefore, is to quantitatively characterize the factors that contribute to altered gait dynamics. The third objective of this application is to develop practical measures of gait dynamics that can be used to augment clinical assessment of chronic disabling disease. In this project, we will study the relationship between chronic disease (i.e., knee osteoarthritis, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis), gait dynamics, and functional status and evaluate how gait dynamics change with disease progression and in response to therapeutic interventions, including exercise and deep brain stimulation. The results of the study will provide new insight into the physiology and adaptations of chronic disease, the efficacy of different therapeutic interventions, and may also provide a new method to augment functional assessment of chronic disability.

初步工作表明，基于步态动态的措施可能 有助于协助慢性疾病和 导致的残疾。大约四九百万美国人有慢性 残疾。这些残疾通常会影响身体机能和流动性， 限制活动，降低独立性并降低生活质量。然而， 缺乏精确，定量和客观的功能衡量 可以在多种设置（例如，在诊所中）限制我们的 能够客观监测疾病进展并评估的功效 新的治疗干预措施。本应用的总体目标是 为了扩展我们的初步发现，以评估步态动力学的度量如何 可用于慢性疾病的功能评估。因为步态动态 可以作为功能能力的敏感且临床相关的指数 评估干预试验，可能有助于提早增强 诊断慢性病，我们认为了解其 起源。因此，该项目的次要目标是定量 表征导致步态动态改变的因素。第三 该应用的目的是制定步态动态的实际度量 可以用来增加对慢性残疾疾病的临床评估。 在这个项目中，我们将研究慢性病（即 膝盖骨关节炎，帕金森氏病，亨廷顿氏病和肌萎缩症 横向硬化症），步态动力学和功能状态并评估步态 随着疾病进展和对治疗的反应，动态变化 干预措施，包括运动和深脑刺激。结果 该研究将为生理和适应的新见解 慢性病，不同治疗干预措施的功效，可能 还提供了一种新方法来增强慢性的功能评估 残疾。