Biomimetic Adhesive for Mineralized Tissues

描述：牙科胶粘剂有主要的局限性，包括：与牙本质的结合强度不足，无法克服复合修复体收缩产生的力；牙缝形成，导致细菌渗入牙齿表面边缘并造成染色；由于聚合物的降解，以及在临床使用过程中对关节的吸水和应力的限制，其耐久性有限。这些限制给患者带来了问题，包括术后牙痛、牙齿健康恶化以及需要昂贵的再次治疗。该项目旨在开发能够在牙齿表面产生可靠和持久粘合的材料。由于仿生方法的发展，这种材料将能够“自我修复”在放置后和临床服务期间立即形成的界面孔隙。此外，这种材料有望成为人体所有硬组织的粘合剂。

DESCRIPTION: Dental adhesives have major limitations, including: inadequate bond strength to dentin to overcome forces generated by contraction of the composite restorative; gap formation that leads to bacterial penetration and staining at the margins with the tooth surface; and limited durability due to polymer degradation and a limitation of the joint from water sorption and stressing during clinical service. These limitations create problems for the patient, including post-operative tooth pain, deterioration of the health of the tooth, and the need for costly re-treatment. This project seeks to develop materials that can produce reliable and durable bonds to tooth surfaces. This material will be capable of "self-healing" the interfacial porosity that forms immediately after placement and during clinical service, due to the development of a biomimetic approach. In addition, this material is expected to be useful as an adhesive for all hard tissues in the body. This work has two long-range goals: 1) Prepare novel, hard tissue adhesive biomaterials with the capacity for self-healing; and 2) identify the mechanism of adhesion and sealing through physical and chemical characterization of the interface between this biomaterial and hard tissues. The main objective is to create a biomimetic process to: 1) Eliminate the formation of nano- and micro-scale leakage at the tooth/adhesive interface; and 2) improve the bond strength between a Dental adhesive material and tooth structure. We will prepare a series of bioactive sol gel glass-containing Dental adhesives, and assess their physical, chemical, and mechanical properties, identifying those compositional factors, structural properties, and placement methods that will improve the seal and bond between the Dental adhesive and the tooth. Additionally we will characterize the changes in the interface between tooth and restoration.