Biomimetic Adhesive for Mineralized Tissues

描述：牙科粘合剂具有主要局限性，包括：与牙本质的粘结强度不足，无法克服复合修复剂收缩产生的力；缝隙形成导致细菌渗透并污染牙齿表面的边缘；由于聚合物降解以及临床服务过程中吸水和应力限制了关节的耐用性。这些限制给患者带来了问题，包括术后牙齿疼痛，牙齿健康恶化，以及需要昂贵的重新治疗。该项目旨在开发能够对牙齿表面产生可靠和持久粘结的材料。由于仿生方法的发展，这种材料将能够“自我修复”在植入后和临床使用期间立即形成的界面孔洞。此外，这种材料有望用作身体所有硬组织的粘合剂。 这项工作有两个长期目标：1)制备具有自我修复能力的新型硬组织黏附生物材料；2)通过对这种生物材料与硬组织之间的界面进行物理和化学表征，确定黏附和封闭的机制。主要目的是创造一种仿生过程，以：1)消除牙齿/粘结剂界面上纳米和微米级渗漏的形成；以及2)提高牙科粘结剂材料与牙齿结构之间的粘结强度。 我们将制备一系列含有生物活性溶胶凝胶玻璃的牙科粘合剂，并对其物理、化学和机械性能进行评估，确定那些将改善牙科粘合剂与牙齿之间的密封性和粘接性的组成因素、结构特性和放置方法。此外，我们还将描述牙齿和修复体之间界面的变化。

DESCRIPTION: Dental adhesives have major limitations, including: inadequate bond strength to dentin to overcome forces generated by contraction of the composite restorative; gap formation that leads to bacterial penetration and staining at the margins with the tooth surface; and limited durability due to polymer degradation and a limitation of the joint from water sorption and stressing during clinical service. These limitations create problems for the patient, including post-operative tooth pain, deterioration of the health of the tooth, and the need for costly re-treatment. This project seeks to develop materials that can produce reliable and durable bonds to tooth surfaces. This material will be capable of "self-healing" the interfacial porosity that forms immediately after placement and during clinical service, due to the development of a biomimetic approach. In addition, this material is expected to be useful as an adhesive for all hard tissues in the body. This work has two long-range goals: 1) Prepare novel, hard tissue adhesive biomaterials with the capacity for self-healing; and 2) identify the mechanism of adhesion and sealing through physical and chemical characterization of the interface between this biomaterial and hard tissues. The main objective is to create a biomimetic process to: 1) Eliminate the formation of nano- and micro-scale leakage at the tooth/adhesive interface; and 2) improve the bond strength between a Dental adhesive material and tooth structure. We will prepare a series of bioactive sol gel glass-containing Dental adhesives, and assess their physical, chemical, and mechanical properties, identifying those compositional factors, structural properties, and placement methods that will improve the seal and bond between the Dental adhesive and the tooth. Additionally we will characterize the changes in the interface between tooth and restoration.