Biomimetic Adhesive for Mineralized Tissues

用于矿化组织的仿生粘合剂

• 批准号: 6954199
• 负责人: JOHN C MITCHELL
• 金额: $ 22.65万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-28 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6954199
• 关键词: adhesions; apatites; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; biomimetics; biotechnology; chemical bond; chemical property; dental adhesive /sealant; glass; microscopy; optics; physical chemical interaction; physical property; restorative dentistry; spectrometry; technology /technique development

DESCRIPTION: Dental adhesives have major limitations, including: inadequate bond strength to dentin to overcome forces generated by contraction of the composite restorative; gap formation that leads to bacterial penetration and staining at the margins with the tooth surface; and limited durability due to polymer degradation and a limitation of the joint from water sorption and stressing during clinical service. These limitations create problems for the patient, including post-operative tooth pain, deterioration of the health of the tooth, and the need for costly re-treatment. This project seeks to develop materials that can produce reliable and durable bonds to tooth surfaces. This material will be capable of "self-healing" the interfacial porosity that forms immediately after placement and during clinical service, due to the development of a biomimetic approach. In addition, this material is expected to be useful as an adhesive for all hard tissues in the body. This work has two long-range goals: 1) Prepare novel, hard tissue adhesive biomaterials with the capacity for self-healing; and 2) identify the mechanism of adhesion and sealing through physical and chemical characterization of the interface between this biomaterial and hard tissues. The main objective is to create a biomimetic process to: 1) Eliminate the formation of nano- and micro-scale leakage at the tooth/adhesive interface; and 2) improve the bond strength between a Dental adhesive material and tooth structure. We will prepare a series of bioactive sol gel glass-containing Dental adhesives, and assess their physical, chemical, and mechanical properties, identifying those compositional factors, structural properties, and placement methods that will improve the seal and bond between the Dental adhesive and the tooth. Additionally we will characterize the changes in the interface between tooth and restoration.

描述：牙齿粘合剂具有主要局限性，包括：与牙本质的键强度不足，以克服复合恢复性收缩产生的力；间隙形成，导致细菌渗透并在边缘染色的牙齿表面染色；以及由于聚合物降解而导致的耐用性有限，并且在临床服务过程中引起的水吸附和压力限制了关节。这些局限性给患者带来了问题，包括术后牙齿疼痛，牙齿健康状况恶化以及需要进行昂贵的重新治疗。该项目旨在开发可以与牙齿表面产生可靠且耐用的粘结的材料。由于仿生方法的发展，该材料将能够“自我修复”位置后和临床服务过程中立即形成的界面孔隙度。另外，该材料有望用作体内所有硬组织的粘合剂。 这项工作有两个远程目标：1）准备具有自我修复能力的新型硬组织粘合物生物材料； 2）通过对这种生物材料和硬组织之间界面的物理和化学表征来确定粘附和密封的机制。主要目的是创建一个仿生过程：1）消除牙齿/粘合剂界面处的纳米和微尺度泄漏的形成； 2）提高牙齿粘合物材料和牙齿结构之间的键强度。 我们将准备一系列含有生物活性胶玻璃胶粘剂的生物活性溶胶，并评估其物理，化学和机械性能，识别这些组成因子，结构特性以及将改善牙齿粘合剂和牙齿之间的密封和键的放置方法。此外，我们将表征牙齿和恢复之间界面的变化。